Journeyman
Senior Member
- Messages
- 193
Hi Folks,
After experiencing some benefits and costs with implementing dietary/supplement changes from my 23&Me results (V3) since mid 2013 I'm now looking to really understand the various SNP's and get past the roadblocks and perhaps have some chance at self actualisation?
I've found some invaluable posts from Valentijn who has both generously given useful analysis and directed me to useful resources, however I need to improve my understanding and abiliity to use those resources. For example I redownloaded my 23&me raw data and started looking at RS numbers of interest.
This then led me to using Valentijn's great '1%' programme which I'm particularly a big fan of since it allows you to get the info you need without putting what might become your most precious personal info out on the interwebs, and at no cost! So I've got some results and I've copied and pasted the RSID's into DbSNPedia but for all of them I get virtually nothing other than one instance which interestingly just said "This is frequently misinterpreted by 23&Me as being GG when its actually AA" - rs8176928
So where to from here? Promethease seems to offer the next best thing after the obligatory (and great) genetic genie but is there anything else.
I was able to use google scholar (great for bringing up peer reviewed journal articles on SNP's of interest) and found one RS which came up as 'homozygous only' in the 1% programme... rs8176928 which relates to SLE (lupus) and then led me to this article - http://online.liebertpub.com/doi/abs/10.1089/dna.2014.2368
Now this seems genuinely useful. I've got a 0.37% SNP polymorphism that is associated with SLE (not sure of the strength of the relationship but it seems apparent)
Is anyone else familiar with this SNP and its implications (Is it strongly linked with SLE?) and if you were in my situation where should I go to understand the interplay of all my SNP's better - a NUTREVAL test seems like the next step... ?
Regards
Journeyman
After experiencing some benefits and costs with implementing dietary/supplement changes from my 23&Me results (V3) since mid 2013 I'm now looking to really understand the various SNP's and get past the roadblocks and perhaps have some chance at self actualisation?
I've found some invaluable posts from Valentijn who has both generously given useful analysis and directed me to useful resources, however I need to improve my understanding and abiliity to use those resources. For example I redownloaded my 23&me raw data and started looking at RS numbers of interest.
This then led me to using Valentijn's great '1%' programme which I'm particularly a big fan of since it allows you to get the info you need without putting what might become your most precious personal info out on the interwebs, and at no cost! So I've got some results and I've copied and pasted the RSID's into DbSNPedia but for all of them I get virtually nothing other than one instance which interestingly just said "This is frequently misinterpreted by 23&Me as being GG when its actually AA" - rs8176928
So where to from here? Promethease seems to offer the next best thing after the obligatory (and great) genetic genie but is there anything else.
I was able to use google scholar (great for bringing up peer reviewed journal articles on SNP's of interest) and found one RS which came up as 'homozygous only' in the 1% programme... rs8176928 which relates to SLE (lupus) and then led me to this article - http://online.liebertpub.com/doi/abs/10.1089/dna.2014.2368
Now this seems genuinely useful. I've got a 0.37% SNP polymorphism that is associated with SLE (not sure of the strength of the relationship but it seems apparent)
Is anyone else familiar with this SNP and its implications (Is it strongly linked with SLE?) and if you were in my situation where should I go to understand the interplay of all my SNP's better - a NUTREVAL test seems like the next step... ?
Regards
Journeyman