Our Newly Ill Face Their First Holiday Season with ME/CFS
Don't look now! The holiday season is on its way. I've lived through decades of them with ME/CFS. So have many of you in our chronically ill community. That's beyond sad for all of us. But at least we have some idea what we're contending with, and have learned our ways of handling...
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Interesting COMT thread

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by wowzer, Jun 1, 2013.

  1. wowzer

    wowzer

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  2. pgoody

    pgoody

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    It's true, and it's particularly true for the prefrontal cortex since the dopamine transporter is mainly in regions of the middle of the brain but not the frontal cortex, meaning that catecholamine O methyltransferase plays a larger role in the frontal cortex: http://www.anthrogenica.com/showthread.php?8-COMT-variation-and-intelligence-(rs4680)

    The difference between Val/val and Met/met alleles will result in a 3-4 fold difference in dopamine catabolism. I myself am Met/met, and since joining this forum have been highly cautious of using any methylation agents. I have had severe panic attacks in reaction to caffeine which I have avoided ever since. There are many many many genetic factors that can lead to increased dopamine here or there (various regions of the brain, as this stuff isn't as 2 dimensional as forums sometimes make it seem, or wish it to be) but the rs4680 I believe is a particularly powerful SNP in its ability to alter dopamine concentrations. Here is a pubmed article discussing the 3-4 fold difference between val/met homozygotes for rs4680 in the summary (just for evidence). http://www.ncbi.nlm.nih.gov/pubmed/16395295
     

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