Insulin suppresses LPS damage in humans

[Waverunner]

Increased amounts of LPS are found in many PWCs. It is interesting that insulin suppresses the normally following stress response in humans. It is pure speculation but could it be possible that foods which provoke insulin release e.g. high sugar foods could help to lower LPS damage e.g. make PWCs feel better in the short run while at the same time bad bacteria feed on the sugar and increase LPS release in the long run?

http://www.ncbi.nlm.nih.gov/pubmed?term= 20699433

Insulin suppresses endotoxin-induced oxidative, nitrosative, and inflammatory stress in humans.

Abstract
OBJECTIVE:
To investigate whether insulin reduces the magnitude of oxidative, nitrosative, and inflammatory stress and tissue damage responses induced by endotoxin (lipopolysaccharide [LPS]).

RESEARCH DESIGN AND METHODS:
Nine normal subjects were injected intravenously with 2 ng/kg LPS prepared from Escherichia coli. Ten others were infused with insulin (2 units/h) for 6 h in addition to the LPS injection along with 100 ml/h of 5% dextrose to maintain normoglycemia.

RESULTS:
LPS injection induced a rapid increase in plasma concentrations of nitric oxide metabolites, nitrite and nitrate (NOM), and thiobarbituric acid-reacting substances (TBARS), an increase in reactive oxygen species (ROS) generation by polymorphonuclear leukocytes (PMNLs), and marked increases in plasma free fatty acids, tumor necrosis factor-? (TNF-?), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), macrophage migration inhibition factor (MIF), C-reactive protein, resistin, visfatin, lipopolysaccharide binding protein (LBP), high mobility group-B1 (HMG-B1), and myoglobin concentrations. The coinfusion of insulin led to a total elimination of the increase in NOM, free fatty acids, and TBARS and a significant reduction in ROS generation by PMNLs and plasma MIF, visfatin, and myoglobin concentrations. Insulin did not affect TNF-?, MCP-1, IL-6, LBP, resistin, and HMG-B1 increases induced by the LPS.

CONCLUSIONS:
Insulin reduces significantly several key mediators of oxidative, nitrosative, and inflammatory stress and tissue damage induced by LPS. These effects of insulin require further investigation for its potential use as anti-inflammatory therapy for endotoxemia.

PMID: 20699433

 

[taniaaust1]

I have hyperinsulinemia and for myself have found having higher insulin levels then normal actually makes my ME worst.. more sore throats, more tiredness, extremely bad moods etc... and hence a very strict diet (less carbs then diabetes patients) so not to set off my insulin too much as actually helped reduce some of my symptoms.
For me.. less insulin is better.. its best for me kept in normal range.

 

[Waverunner]

Thanks so much for your reply, Tania. I already wanted to ask if someone has his insulin levels checked and can report on his experiences but I didn't think that anyone has because normally only blood sugar is measured. It would still be interesting however to know, why sugar causes so much trouble for most of us. Do bacteria feed on it, does it reduce vitamin efficiency/levels, does it suppress the immune system or are there even other reasons?

 

[aprilk1869]

These are just some of my thoughts relating to insulin which might be of interest. I'm in no way an expert on the subject.

Many stressors (including bacterial infections) cause cortisol to rise which in turn causes insulin resistance. Excess cortisol also suppresses the immune system making it more difficult to fight off infections.

Alzheimer's has been called by some researchers "diabetes of the brain" or "diabetes type 3." If insulin receptors in the brain are resistant to insulin, glucose can't get into the cells therefor the brain cells become starved and can't function properly. Alzheimer's has also been linked to viral and bacterial infections.

I'm not sure if other neurological illnesses have been studied in relation to insulin however there appears to be a connection to MS.

Type I Diabetes and Multiple Sclerosis Patients Target Islet Plus Central Nervous System Autoantigens; Nonimmunized Nonobese Diabetic Mice Can Develop Autoimmune Encephalitis
http://www.jimmunol.org/content/166/4/2831.full.pdf

Researchers Determine That MS And Diabetes Are Closely Linked Diseases
http://www.sciencedaily.com/releases/2001/03/010322074643.htm

Prevalence of Diabetes in Patients With Multiple Sclerosis
http://care.diabetesjournals.org/content/29/8/1984.1.full

Insulin resistance, inflammation, and cognition in Alzheimer's Disease: lessons for multiple sclerosis.
http://www.ncbi.nlm.nih.gov/pubmed/16631207

Diabetes drug pioglitazone shows potential against multiple sclerosis
http://www.news-medical.net/news/20...ows-potential-against-multiple-sclerosis.aspx
(the above drug is also called Actos and I beleive Dr Shoemaker uses it on patients)

My mum was officially diagnosed with MS however I'm not totally convinced by the diagnosis for a number of reasons including the fact that she was on a very low b12/fat diet at the time and I this could mimic MS. She was also obsessed with exercise and excessive exercise has been associated with fatigue-type illnesses. It depletes a lot of resources and increases cortisol.

The onset of her illness involved double vision which could be because of a b12 deficiency. Insulin resistance can also cause double vision.

My maternal grandmother had diabetes type 1 and my Great Aunt is currently pretty far gone with Alzheimer's.

I wondered if there was a connection between insulin and b12 and surprisingly came up with a lot of info although I don't really understand much of it. I knew that b12 has successfully been used to treat diabetic neuropathy but didn't think any more about it.

Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: relationship between homocysteine levels and hyperinsulinemia
http://www.eje.org/content/151/4/483.short

Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study
http://www.springerlink.com/content/b436104175k10x08/

Exploring the implications of vitamin B12 conjugation to insulin on insulin receptor binding.
http://www.ncbi.nlm.nih.gov/pubmed/19101970

Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles
http://www.sciencedirect.com/science/article/pii/S0168365907002635

Insulin sensitivity and plasma homocysteine concentrations in non-diabetic obese and normal weight subjects
http://www.sciencedirect.com/science/article/pii/S0021915002003866

I think issues with insulin can also be linked to many other illnesses including asthma and osteoarthritis, both of which affect my gran (my mum's mum). It would seem that if you don't produce enough insulin or your receptors are resistant to it, then you're at risk of not being able to fight infections.

Interestingly the antimalarial drug Hydroxychloroquine is being used by those with rheumatoid arthritis, lupus and psoriasis, it seems to have insulin-sparing effects.

http://www.ncbi.nlm.nih.gov/pubmed/10535702
http://www.arthritistoday.org/condi...ritis/news-and-research/antimalarial-drug.php
http://jama.ama-assn.org/content/305/24/2525

It appears that Hydroxychloroquine can also be used in the treatment of Lyme Disease.
http://www.ncbi.nlm.nih.gov/pubmed/15617845

 

[aprilk1869]

These are links that I've collected and might be of interest to some.

Magnesium Deficiency Is Associated With Insulin Resistance in Obese Children
http://care.diabetesjournals.org/content/28/5/1175.long

Diabetes and Magnesium: The Emerging Role of Oral Magnesium Supplementation
www.mgwater.com/diabetes.shtml

Sodium lactate increases LPS-stimulated MMP and cytokine expression in U937 histiocytes by enhancing AP-1 and NF-KB transcriptional activities
http://ajpendo.physiology.org/content/289/4/E534.full


Local insulin injection improves median nerve regeneration in NIDDM patients with carpal tunnel syndrome.
http://www.ncbi.nlm.nih.gov/pubmed/11422429
(My mum's mum has had 2 surgeries for CTS)

Effects of intravenous infusion of lipopolysaccharide on plasma micromineral, magnesium, and cytokine concentrations and serum cortisol concentrations in lactating goats.
http://www.ncbi.nlm.nih.gov/pubmed/17472454?dopt=AbstractPlus
(LPS decreased zinc levels)

Lipopolysaccharide-Activated B Cells Down-Regulate Th1 Immunity and Prevent Autoimmune Diabetes in Nonobese Diabetic Mice
http://www.jimmunol.org/content/167/2/1081.full

Low maternal vitamin B-12 status is associated with offspring insulin resistance regardless of antenatal micronutrient supplementation in rural Nepal.
http://www.ncbi.nlm.nih.gov/pubmed/21865563

Common Link Suggested Between Autism and Diabetes: Study Implicates Hyperinsulinemia in Increased Incidence of Autism
http://www.sciencedaily.com/releases/2011/10/111019184622.htm

very good website http://microbialinfluence.com/

 

[redo]

+1 for the info and the links april. Fascinating to see how closely linked the syndromes MS and diabetes really are. Add to the list, Rituximab has been shown to help both MS and diabetes. I am really thinking there's got to be some sort of common nominator for some of the syndromes given the similarites.