I think it is inflammation i am experiencing but not 100% sure. I have these sudden outbreaks or attacks and my brain feels aching sore as well as my eyes and all through my muscles in arms, legs, my throat feels inflamed, my breathing doesn't feel right. I also feel extremely on edge and anxious, and noise really bothers me. Like my partner was rustling paper loudly and it actually felt painful. I'm just glad i don't get this all the time. Probably about once a month on average with a very bad day and then a gradual reduction over several days. I'm guessing other people here get this as most of us share the same symptoms, but it feels good to know your not alone. For people with more medical knowledge, is this likely to be what happens with brain inflammation, that it affects the whole body? I was just wondering how it works. It's frustrating that i can't read lots and research it all for my self. Also, It says this on the UK NHS website: "Chronic fatigue syndrome (CFS) is the term often used and preferred by doctors because there is little evidence of brain and spinal cord inflammation, as the term ME suggests." Page is from 2014. I was just wondering if this is true or if there is good evidence now. I think i remember Jarred Younger found increased temperature of the brain in people with M.E. I'm not sure how concrete that evidence is though.