For anyone who’s seen my posts the past 6 months, I’ve been chasing the methylation tail, but I’m wondering if I’m doing the wrong thing first. Every time I take methylfolate and methylcobalamin, I get terrible muscle tightness, angular cheilitis develops, and I hold water in my face and abdomen and gut feels distended/bloated. When I switch to a multi that uses folic acid and cyanocobalamin, the angular cheilitis heals, I have full Range of motion in arms and shoulders but I have zero energy, no memory at all and it’s really hard to get out of bed, but I don’t feel *inflamed* and I lose the water weight. If I don’t take anything, histamine gets crazy, lump in throat, difficulty breathing, etc. Is the methylated vitamins bringing out a Candida or some other infection? The angular cheilitis is what’s getting me confused. A few days ago, I took 1 gram of MSM, and by the end of the day had a headache, next morning had several pimples, itchy in arm pits and around ankles and had awesome bowel movements (TMI?). Was that a detox(Herx)? Does anyone have any suggestion what to do next? Thanks in advance. For the record, my ferritin is good enough and I take plenty of b2, zinc so shouldn’t be any deficiency.