These last few weeks have been the most miserable I've had in the last 9 years. I had onset of Hypokalemia with the worst of all the spasms I've had in a decade. I also have had to take Metoclopromide (causes peristalsis to start up) every day for the last 3 weeks, the first time in more than 10 years for that, no appetite, nausea, bloating etc all for the first time in more than 10 years. Along with that went the worst angular cheilitis and worst IBS, possibly in my life. The cheilitis was actually bleeding and left a scab. Also I had skin infections that looked like staph and wouldn't respond to Neosporin and were expanding rapidly. Fortunately lavender oil (essential oil) knocked them right out. Further, in just 3 weeks, the foot numbness increased significantly. Again, all that goes back more than 10 years. No amount of potassium and no amount of Metafolin that I was willing to try (both items) did more than keep things from getting worse. Metoclopromide (generic for Reglan) works very well at restoring peristalsis, fortunately. However, extended daily usage can cause tardive dyskinesia which can be permanent. So now what happened? I have been doing some trials on B-vitamin separates to see if I can improve my balance of vitamins. Several weeks ago I added 100mg B2 and 100mg B3. I took that for 4 days, the number of days’ doses I made up at one time. On day 2 I started with muscle spasms, day three angular cheilitis and day 4 severe IBS and general stomach and intestinal paralysis. When I made up the next 4 days worth the B3 bottle had gone missing so I discontinued that. The only addition then was B2. The next 4 days got worse and worse. I have never had bleeding cheilitis before. I have never needed Metoclopromide for more than a few days a month before. After dropping the B2 after those next four days the cheilitis started backing off slowly. The IBS slowly got better. I was able to reduce the Metoclopromide dose by 50% and now have gone 2 days without.. After a couple of more weeks the nausea has subsided and I was actually hungry the past 2 days. The low potassium symptoms have subsided slowly, as might be expected from a “fast compartment” and “slow compartment” model as potassium has; serum and tissue compartments. So now, let’s figure this out. Others have mentioned similar results, from paralyzed ileum to insatiable need for Metafolin and potassium. This acts like a startup from hell, overdoing this most extremely. So the question that comes up, is THIS effect then the actual result of “overmethylation” or what should it be called? Yes, I know, it is once again “DETOX”, and once again that is meaningless.. Are B2-B3 somehow the accelerators? Balance appears to be somehow the key to this all. Order is important in this. It looks like the “last thing in” is the accelerator. However, with B2 at least there is proportionality. With 20mg of B2 daily I have intermittent low potassium and low methylfolate but also extensive healing. B12 and methylfolate appear to turn on very strongly with little proportionality. L-carnitine has very strong proportionality. B2 and/or B3 (not sure of interaction here) has a strong proportionality as there is an amount that allows healing to take place without these severe problems and an adequate balance across the whole range of healing. With too much B2 the side effects get far worse and healing stops and even reverses. I see a bottle of LOW dose B2 in my future with which I can titrate to best effect and maybe get rid of these intermittent low folate and low potassium effects, or at least find out how they relate. Clearly B2 is very dose proportional in it’s effect and is a most limiting factor at times and appears to be able to drive certain processes beyond useful limits as has been hypothesized about other things like B12 and folate. This appears to be the “throttle” that at least some of us have been looking for.