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Increased risk of chronic fatigue syndrome following herpes zoster

Discussion in 'Latest ME/CFS Research' started by Ecoclimber, Apr 11, 2014.

  1. Ecoclimber

    Ecoclimber Senior Member

    Eur J Clin Microbiol Infect Dis. 2014 Apr 9. [Epub ahead of print]
    Increased risk of chronic fatigue syndrome following herpes zoster: a population-based study.
    Tsai SY1, Yang TY, Chen HJ, Chen CS, Lin WM, Shen WC, Kuo CN, Kao CH.
    Author information


    Chronic fatigue syndrome (CFS) is a complex disorder accompanied by unexplainable persistent fatigue, in which several etiological factors exist, such as viral infections. Using the National Health Insurance Research Database (NHIRD) of Taiwan, this study evaluated the association between herpes zoster (HZ) infection and the risk of CFS, and examined the possibility of patients developing postviral fatigue effects, including the possibility of developing other unexplainable chronic fatigue conditions.

    In this prospective cohort study using the NHIRD, we identified 9,205 patients with HZ infection [ICD-9 (International Classification of Disease, Ninth Revision), code 053] and 36,820 patients without HZ infection (non-HZ) from 2005 to 2007, and followed up to the end of 2010. The incidence rate of CFS was higher in the HZ cohort than in the non-HZ cohort (4.56 vs. 3.44 per 1,000 person-years), with an adjusted hazard ratio of 1.29 [95 % confidence interval (CI) = 1.09-1.53]. It was shown that the risk of CFS without comorbidity for each patient increased from 1.25- to 1.36-fold between the CFS and non-CFS cohorts; with long-term follow-up, the HZ cohort showed a significantly higher cumulative incidence rate of developing CFS than the non-HZ patients.

    We propose that patients with chronic fatigue might exist in a subset of patients that would be associated with HZ infection. The actual mechanism of development of CFS that is attributed to HZ infection remains unclear. The findings of this population cohort study provide pivotal evidence of postviral fatigue among patients with HZ infection
  2. AndyPandy

    AndyPandy Making the most of it

    I had herpes zoster (shingles) 30 years before developing ME/CFS. My immune system was compromised before developing herpes zoster and again before ME/CFS.
  3. anciendaze

    anciendaze Senior Member

    This is significant in several ways: VZV is well known to infect humans; it can lie latent for many years; it is known to infect the dorsal root ganglia. The dorsal root ganglia are the major centers for processing information going into the brain via the spinal cord. Damage there produces signals apparent to patients, but not to doctors.

    VZV is a herpes-type DNA virus, related to EBV, HSV, CMV and HHV6/7.

    Aside: VZV is fairly similar to the virus causing Marek's disease in chickens. The name chicken pox indicates the connection was recognized long ago.
    NK17 likes this.

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