Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
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Immune Abnormalities in Fukuda CFS patients vs ICC ME patients (Griffith Uni)

Discussion in 'Latest ME/CFS Research' started by Simon, Dec 3, 2013.

  1. Simon


    Monmouth, UK
    A new paper from Griffith University finds immune differences between healthy controls and Me/CFS patients, and correlations between physical status and a few immune markers in ICC ME patients (ie the more physical problems, the stronger the differences in immune markers).

    Immune Abnormalities in Patients Meeting New Diagnostic Criteria for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
    Brenu EW1,2*, Johnston S1,2, Hardcastle SL1,2, Huth TK1,2, Fuller K1,2, Ramos SB1,2, Staines DR2,3 and Marshall-Gradisnik SM1,2

    Free full text (Open Access) pdf available here, but as yet not showing on the journal website. Official link (when live)

    (Edit by Snow Leopard) PDF is here:

    Note that the sampe size is rather small: 18 ICC ME patients, 17 CDC-94 (Fukuda) patients and 22 healthy controls. Also Fukuda & ICC were diagnosed by questionnaire, not physician examination and tests, but patients already had an ME/CFS diagnosis (details of how orginally diagnosed not given); 5 patients originally diagnosed with mecfs did not meet either criteria.


    Background: Immunological abnormalities have been identified in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients fulfilling the 1994 Centers for Disease Control diagnostic criteria [aka Fukuda].

    Significant developments have been made to diagnostic criteria, but potential immunological markers have not been assessed in patients fulfilling these latest clinical requirements. Therefore, this study evaluated immunological parameters in patients that also fulfill the latest diagnostic criteria available known as the International Consensus Criteria.

    Methods: The Immunological investigations including Natural Killer cell activity and phenotyping studies for dendritic cells [antigen-presenting], neutrophils, B cells and regulatory T cells were performed on whole blood samples collected from all participants using flow cytometric protocols.

    The physical functioning of all participants was also evaluated using scores from the Short Form Health Survey, and the World Health Organization Disability Adjustment Schedule.

    Results were compared according 1994 Centers of Disease Control and Prevention defined patients, and International Consensus Criteria defined patients, and healthy controls.

    Results: Natural killer cell activity was consistently and significantly decreased, and regulatory T cells were significantly increased in both patient groups compared to healthy controls.

    Differences were found in human neutraphil antigens and expression of natural killer cell receptors between patient groups.

    Highly significant correlations were also found between physical status and some immune parameters in International Consensus Criteria defined patients.

    Conclusion: This preliminary investigation on different diagnostic criteria suggests that the ICC may be more effective a detecting salient differences in the immune system.
    Last edited by a moderator: Dec 3, 2013
    MeSci, Nielk, Valentijn and 2 others like this.
  2. heapsreal

    heapsreal iherb 10% discount code OPA989,

    australia (brisbane)
    They used the fukuda criteria for the 18month nk function testing study the did a few yrs ago.
    Good to see there using a better criteria.
    Valentijn and RustyJ like this.
  3. Purple

    Purple Bundle of purpliness

    Anyone knows what the 'World Health Organization Disability Adjustment Schedule' is?
  4. Simon


    Monmouth, UK
    More detailed findings on ICC v Fukuda

    Two different findgs distinguished ICC from Fukuda-only patients:

    The significance of this isn't clear.

    Immunoglobulin Receptors on Natural Killer cells (KIRs) increased in ICC patients
    However, these KIRs were not significantly different from controls, and there was no difference NK cytotoxicity between ICC & Fukuda patients. The authors suggested that this might indicate a different mechanism for reduced NK cytotoxicity in ICC and Fukuda patients.

    However, as the authors note in their abstract, these are provisional findings and given the small sample sizes replication is particularly important.
    merylg, Dolphin, MeSci and 2 others like this.
  5. Gijs

    Gijs Senior Member

    What is the news? Reduced NK cytotoxicity is known for a long time now in CFS. Nobody cares in the medical community. It is not useful as a marker.
  6. Firestormm


    Cornwall England
    @Simon I think this is the link that takes you to the full paper.

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