Full paper mentions CFS somewhere. Leonard Jason talks about kindling in ME/CFS which is perhaps similar.
Future Medicinal Chemistry
November 2012, Vol. 4, No. 17, Pages 2177-2192 , DOI 10.4155/fmc.12.156
(doi:10.4155/fmc.12.156)
Perspective
Role of IL-6 in the etiology of hyperexcitable neuropsychiatric conditions: experimental evidence and therapeutic implications
Marco Atzori*1, Francisco Garcia-Oscos1 & Jose Alfredo Mendez2
* Author for correspondence
Many neuropsychiatric conditions are primed or triggered by different types of stressors.
The mechanisms through which stress induces neuropsychiatric disease are complex and incompletely understood.
A ‘double hit’ hypothesis of neuropsychiatric disease postulates that stress induces maladaptive behavior in two phases separated by a dormant period.
Recent research shows that the pleiotropic cytokine IL-6 is released centrally and peripherally following physical and psychological stress.
In this article, we analyze evidence from clinics and animal models suggesting that stress-induced elevation in the levels of IL-6 may play a key role in the etiology of a heterogeneous family of hyperexcitable central conditions including epilepsy, schizophrenic psychoses, anxiety and disorders of the autistic spectrum.
The cellular mechanism leading to hyperexcitable conditions might be a decrease in inhibitory/excitatory synaptic balance in either or both temporal phases of the conditions.
Following these observations, we discuss how they may have important implications for optimal prophylactic and therapeutic pharmacological treatment.