IL-10 modulation of Sleep

[energyoverload]

Hi

I know there are quite a few conflicting results regarding protein level of IL-10 in PBMC's etc. in ME. But what I found interesting, in the context of myself being a very partial Rituximab responder:

Inhibition of interleukin 10 by rituximab results in down-regulation of bcl-2 and sensitization of B-cell non-Hodgkin's lymphoma to apoptosis.
http://www.ncbi.nlm.nih.gov/pubmed/11297268

I had several periods only lasting for the most part of a day at a time where practically all symptoms seemed to normalise (even sleep, a symptom I have found very hard to manipulate other than through sedation, reduction neuroexcitation etc.)
Infact the time I felt best whilst undergoing B cell depletion was when I acquired a bout of Bronchitis. Quite possibly Th1 cytokines were more able to manifest during a period of reduced IL-10 secretion

So in theory:
(-) IL-10 --> (+) PBMC response to TLR agonist challenge (LPS etc.) --> (+) Th1 production (enabling presentation of physical manifestations of infection - of which I am from the subgroup that hardly ever catches any flu)

I also wonder if some IL-10 disturbance could be having implications on Circadian Rhythm:

http://www.ncbi.nlm.nih.gov/pubmed/11353686
Cytokine- and microbially induced sleep responses of interleukin-10 deficient mice.

 

[Beyond]

That´s a fascinating study, thank you. This info needs to be mixed with other to gather something useful though.

Not completely on topic, but have you ever had cytokines tested? To know how your Th1 and Th2 cytokines are and if it has any significance to your illness. IL-10 from what I have gathered is sort of a regulator of Th1 activity, regulator meaning suppressor in case of overactivity.

The thing with IL-10 blocking Th1 responses is that this "guy" isn´t all that bad news, as things like tumour necrosis alpha mean autoimmunity so if IL-10 it is elevated that could be a protection measure of your body.

From your study and these http://www.karger.com/Article/Abstract/71474 http://europepmc.org/abstract/MED/20036927 we could draw a hypothesis that indeed Th2 cytokines either cause or are related with sleep problems. This goes well with my current idea of having "Th2 dominance", although as studies show, in fact people with atopy or allergy (th2) do tend to have more autoimmunity (th1) so the th1/th2 model as even wikipedia says is not the whole story. The immune system is still obscure.

"In regards to the correlation between immune alterations and insomnia, it has been shown that chronic insomnia patients exhibit a reduction of CD3+, CD4+ and CD8+ cells50 and a predominance of Th2 response, i.e., enhanced humoral immune response"