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IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections

Discussion in 'Other Health News and Research' started by Kati, Dec 16, 2016.

  1. Kati

    Kati Patient in training

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    IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections

    http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005973


    Abstract:

    The host inflammatory response against infections is characterized by the release of pro-inflammatory cytokines and acute-phase proteins, driving both innate and adaptive arms of the immune response.

    Distinct patterns of circulating cytokines and acute-phase responses have proven indispensable for guiding the diagnosis and management of infectious diseases.

    This review discusses the profiles of acute-phase proteins and circulating cytokines encountered in viral and bacterial infections.

    We also propose a model in which the inflammatory response to viral (IL-18/ferritin) and bacterial (IL-6/CRP) infections presents with specific plasma patterns of immune biomarkers.
     

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