I'll mention this briefly as there doesn't seem to be a post on this already. 400mg of ibuprofen significantly reduces my fatigue, I can act almost normally (i.e. go walking) for a couple of hours with minimal payback and reduced PEM. I've tried this many times now and always notice an effect. I don't take it every day for fear that it will lose its effect. Since it's cheap, it might be worth trying. I assume it works by modulating my immune system.