http://www.pnas.org/content/early/2013/02/07/1222878110.abstract Large-scale genomic study reveals the human and mouse immune system are dissimilar contrary to conventional thinking. Yesterday's NY Times: "Researchers report evidence the mouse model has been totally misleading for at least three major killers--sepsis, burns and trauma. As a result, years and billions of dollars have been wasted following false leads. The study's findings do not mean that mice are useless models for all human diseases. But its authors said, they do raise troubling questions about diseases like the ones in the study that involve the immune system, including cancer and heart disease." Mouse models are widely used for drug development & testing and to study disease pathogenesis.