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How Viral Infection Disrupts Neural Development

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natasa778

Senior Member
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1,774
http://www.sciencedaily.com/releases/2013/09/130926204727.htm



The researchers found that the high MHCI levels impaired the ability of the neurons from the newborn mice's brains to form synapses...

The researchers experimentally reduced MHCI to normal levels in neurons from offspring following maternal immune activation.

"Remarkably, synapse density returned to normal levels in those neurons," McAllister said.

"These results indicate that maternal immune activation does indeed alter connectivity during prenatal development, causing a profound deficit in the ability of cortical neurons to form synapses that is caused by changes in levels of MHCI on the neurons," she said.

...
"This finding provides a potential mechanism linking maternal immune activation to disease-linked behaviors," McAllister said.
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