How to improve getting up in the morning?

[Alvin2]

I think Ceretropic are the only vendor to carry it, you have to reconstitute it yourself though seeing that it's a long sequence peptide so it's fragile. It needs to go in the fridge too.

Interesting, though their website says
This compound has not been approved by the FDA and should be used for research purposes only.
Hopefully that means its fit for human consumption

 

[arewenearlythereyet]

Interesting, though their website says
This compound has not been approved by the FDA and should be used for research purposes only.
Hopefully that means its fit for human consumption

I had a quick look ....it seems to up regulate appetite and testosterone as well? I think it's been tested on primates so far.

There is a bit of blurb on this site with a few links to research

http://www.musclefuture.com/productdetails.aspx?id=12760

 

[Lethargic]

I try and drink something when I first get up and lay back down.I notice on mornings after I take Ativan at bedtime are easier.

 

[Alvin2]

I had a quick look ....it seems to up regulate appetite and testosterone as well? I think it's been tested on primates so far.

There is a bit of blurb on this site with a few links to research

http://www.musclefuture.com/productdetails.aspx?id=12760

i know a great deal about orexin, it basically orchestrates wakefulness, and i doubt it will help much for our sleep problem since its caused by ME/CFS and not narcolepsy (which is caused by destruction of orexin generating neurons leading to sleep attacks, cataplexy and REM sleep abnormalities which are very different then our sleep issues).
Several of the sleep doctors i have seen are also narcolepsy specialists and thats not what this problem is, it was ruled out pretty quickly.

 

[arewenearlythereyet]

i know a great deal about orexin, it basically orchestrates wakefulness, and i doubt it will help much for our sleep problem since its caused by ME/CFS and not narcolepsy (which is caused by destruction of orexin generating neurons leading to sleep attacks, cataplexy and REM sleep abnormalities which are very different then our sleep issues).
Several of the sleep doctors i have seen are also narcolepsy specialists and thats not what this problem is, it was ruled out pretty quickly.

Yep...agree with you, just posting.

 

[Seven7]

Hi @Inester7. I have OI and possibly POTs so I've been considering upping my fluids from the 1.5l I drink at the moment. I've done a rough home test for POTs which did show elevated heart rate upon standing (60 resting goes to high 80's low 90's standing) but have been reluctant to go to the GP to get a tilt table test etc even though there is a specialist quite near to me in the UK.

Any ideas about what level of fluids to target with the electrolytes? Or whether there is a good electrolyte blend for OI? I think I'm supposed to be having more sodium but have done nothing yet in this area. I guess dehydration overnight may be an issue for the waking symptoms?

I feel best on 3L even thgoutb I was told a gallon, when I do a gallon, the pressure of the head increases ( when I over hydrate, burning on head gets strong).
There are a few good electrolytes, nuun tablets, my favorite is Pedyalite. But just google I am sure you will find. We are all different you will have to try.

About the total amount it doesnt matter for your issue, the issue is that we have to drink the glass before getting out of bed so that timing is important to get the morning going. I hope you get to see a Dr for your OI I feel there is so much drugs for OI that can help with Cfs. So I think is worth a try.

 

[Tunguska]

Your POTS throws a wrench into things. Fixing this became urgent priority for me recently but anything I write could backfire on you.

I accidentally improved my symptoms in the last weeks while taking large doses of 5-alpha-DHP + low caffeine in the morning more regularly, every 2 days or so. Waking up has become progressively easier. I have no clear idea how it's doing this (this is a 15-year problem so it's no small deal) other than the allopreg modulates dopamine a bit. Also changed diet a bit to a monofibre diet (dates only) so maybe the gut is interfering less.

Before this "accident" I was planning on trying an ALA + niacinamide protocol. As in single large dose of ALA (600mg+) in the morning and moderately high dose of niacinamide at supper time (300-700mg). They're both used in the research to influence rhythm and it's just a matter of getting the timing right. But I don't know how well they compare to glucocorticoids or orexin, it was just first things first.

 

[nandixon]

I accidentally improved my symptoms in the last weeks while taking large doses of 5-alpha-DHP + low caffeine in the morning more regularly, every 2 days or so. Waking up has become progressively easier. I have no clear idea how it's doing this (this is a 15-year problem so it's no small deal) other than the allopreg modulates dopamine a bit.

Did you see this 2012 study?:

The neurosteroids, allopregnanolone and progesterone, induce autophagy in cultured astrocytes.

Allopregnanolone was shown to activate Akt/mTOR in (mouse) astrocytes. So possibly a connection there.

 

[antherder]

Those were the days indeed .....I also used caffeine and nicotine.....annoyingly it was immediately after I gave up smoking that I got ill with this horrid disease.

Did you see this thread a while back? Had some interesting stuff re nicotine being used for treating ME. Not suggesting you try it, just mentioning as you said you got sick after you stopped smoking.

http://forums.phoenixrising.me/index.php?threads/does-anyone-here-smoke.48975/

Also, fasting hypoglycemia can cause some similar morning symptoms.

 

[Gondwanaland]

Also, fasting hypoglycemia can cause some similar morning symptoms.

How about fasting hyperinsulinemia? My husband can't get out of bed in the morning and he has fasting hyperinsulinemia but no hypoglycemia. I tried giving him my probiotics, but since I have IBS-C and he has IBS-D it didn't work.

 

[PatJ]

When I wake up it is seriously unpleasant (nausea, dizzy, muscle aches, headaches etc.). This fades after around an hour to 2 hours.

I get up at 4am to prepare food and eat before 4:30am when my blood sugar starts to drop. If I try to sleep through this period then I wake up feeling nauseous, dizzy, uncoordinated, have deep brainfog, and a headache that last from hours to all day. I have to eat 10 small meals during the day to keep my blood sugar stable, but don't have any blood sugar problems at night. Because of this problem I have shifted my sleep cycle so that I go to bed at 7pm and wake at 4am.

Waking is easy now and I don't feel dismal as long as I keep my blood sugar stable -- which means eating before symptoms arise, not waiting until they hit. Once blood sugar starts to drop it sets off a cascade of stressful reactions in the body. Eating before this happens will reduce the stress on the body.

 

[Gondwanaland]

@PatJ Did you have a poor outcome from a low carb/keto diet? My husband can't get past a low carb breakfast without severe depression. However, he once did a 24h fasting and felt great, but didn't want to repeat the experience.

 

[PatJ]

@PatJ Did you have a poor outcome from a low carb/keto diet? My husband can't get past a low carb breakfast without severe depression. However, he once did a 24h fasting and felt great, but didn't want to repeat the experience.

Last year I tried low carb for a few days but had so little energy that I had to increase my carbs again. I also lose weight like crazy unless I have a high carb intake (and I'm already severely underweight.)

A few years ago I tried skipping evening meals and found that my balance was so poor that I would collide with walls when walking down a hallway. I didn't realize then that I was experiencing hypoglycemia symptoms. I think a full 24 hour fast would leave me comatose.

 

[Gondwanaland]

I also lose weight like crazy unless I have a high carb intake (and I'm already severely underweight.)

That is my case as well.

 

[Tunguska]

Did you see this 2012 study?:

The neurosteroids, allopregnanolone and progesterone, induce autophagy in cultured astrocytes.

Allopregnanolone was shown to activate Akt/mTOR in (mouse) astrocytes. So possibly a connection there.

Thanks nandixon, I did, because the simultaneous mTor + autophagy caught my eye. There's also some articles that discuss that allo may increase BDNF, but the link seems weak. Progesterone is a little two-faced so you could expect something similar from allo. That said I think dosage makes all the difference so maybe it does toward the mTor activation too. I still aim for the mTor thing besides this (the ALA thing is single dose short half life, don't think will be an issue). *How much it influences the clock is open to question though.

 

[Tunguska]

I walked right past this one, it's kind of embarrassing
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936666/

Low brain allopregnanolone levels mediate flattened circadian activity associated with memory impairments in aged rats

Results
Similar to observations in humans, a subpopulation of middle-aged and aged rats show flattened amplitude of circadian activity associated with impaired spatial long-term memory performance. Sleep-dependent memory dysfunction was associated with a low level of allopregnanolone in the hypothalamus, pedunculopontine nucleus, and ventral striatum. Inhibition of allopregnanolone synthesis in young rats decreased allopregnanolone in the hypothalamus and produced flattened amplitude of circadian activity similar to aged rats.

Conclusions
These findings identify brainstem and basal forebrain allopregnanolone as an essential endogenous substrate involved in mediating sleep-dependent memory function in young and aged rats. Allopregnanolone may play a critical role in preserving individuals from age-induced alterations in sleep and memory processes and may represent a novel target for attenuating age-related declines in sleep and memory.

 

[Alvin2]

I walked right past this one, it's kind of embarrassing
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936666/

Lets keep in mind there are about a million things that affect the circadian rhythm, from vitamin D to what time you eat. Finding the exact mechanism for our case without a qualified test is like finding a non magnetic needle in 10 haystacks, you might as well buy a lottery ticket. We don't even know if its a circadian issue.
I had to learn this lesson the very hard way, over two decades later here i am

 

[Tunguska]

Lets keep in mind there are about a million things that affect the circadian rhythm, from vitamin D to what time you eat. Finding the exact mechanism for our case without a qualified test is like finding a non magnetic needle in 10 haystacks, you might as well buy a lottery ticket. We don't even know if its a circadian issue.
I had to learn this lesson the very hard way, over two decades later here i am

Yeah absolutely. But so far I got 2 numbers out of 6 and in 3 months I'll let you know how the rest went.

 

[CFS_for_19_years]

For me, taking DHEA in the morning gets rid of the feeling of having been hit by a truck on successive mornings.

 

[Hyperflux]

Here's the Wikipedia on the Orexin spray: https://en.wikipedia.org/wiki/Orexin-A
I can post a review after using it for a month or two. I reconstituted my bottle so each spray is 50ug, I'll try 1-2 sprays.