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How the Body Uses Vitamin B to Recognize Bacterial Infection

Discussion in 'Other Health News and Research' started by Glynis Steele, Oct 11, 2012.

  1. Glynis Steele

    Glynis Steele Senior Member

    Newcastle upon Tyne UK
    ScienceDaily (Oct. 10, 2012) — An Australian research team has discovered how specialised immune cells recognise products of vitamin B synthesis that are unique to bacteria and yeast, triggering the body to fight infection.

    The finding opens up potential targets to improve treatments or to develop a vaccine for tuberculosis.
    The study, jointly led by the University of Melbourne and Monash University and published today in the journal Nature, has revealed for the first time that the highly abundant mucosal associated invariant T cells (MAIT cells), recognise products of vitamin B synthesis from bacteria and yeast in an early step to activating the immune system.

    The research revealed how by-products of bacterial vitamin synthesis, including some derived from Folic acid or vitamin B9 and Riboflavin or vitamin B2, could be captured by the immune receptor MR1 thus fine-tuning the activity of MAIT cells.

    Dr Lars Kjer-Nielsen from the University of Melbourne led the five year study.
    "Humans are unable to make vitamin B and obtain it mostly from diet. Because bacteria can synthesise vitamin B, our immune system uses this as a point of difference to recognise infection," he said.

    "Given the relative abundance of the MAIT cells lining mucosal and other surfaces, such as the intestine, the mouth, lungs, it is quite probable that they play a protective role in many infections from thrush to tuberculosis. This is a significant discovery that unravels the long sought target of MAIT cells and their role in immunity to infection."

    Full article: http://www.sciencedaily.com/releases/2012/10/121010131444.htm
    Asklipia, dece, nanonug and 1 other person like this.
  2. alex3619

    alex3619 Senior Member

    Logan, Queensland, Australia
    I wonder how this impacts on the methylation hypothesis?
    dece and taniaaust1 like this.
  3. taniaaust1

    taniaaust1 Senior Member

    Sth Australia
    Thanks for posting this.. a few days ago I found out that due to the polymorphism I have.. the folate my other specialist had me on for years for my issue.. is no good in helping for the problem as I need active form of it.

    I think this new research could be relevent to many of us in putting a lot more importance in things such as folate.

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