Can 200mcg methylfolate be great for someone but 300mcg causes them to overmethylate? Or would it likely be a larger dose, like 1000mcg or more? I was reading on this site where this guy who was doing a balancing act between methylfolate and niacin. http://mthfr.net/overmethylation-and-undermethylation-case-study/2012/06/27/ Thats what I kind of feel like im doing atm. Because I am just biting into an 800mcg pill as opposed to using a pill spliter for a more accurate dose, I could be getting between 200-400mcg. So, initially I had my good/tolerant reaction, then last night I started to feel very anxious. I took 50mg of niacin and felt better not long after. This has happened a few times before with methylfolate. Whats your experience?