Maybe it's not the right forum section, but vitamin D3 should be part of my methylation protocol so I guess it makes sense to post it here. Long story short, I am supposed to take D3 supplements but orally I can hardly take 400IU and then my digestion gets upset. So I bought a D3 cream in order to bypass the stomach and be able to get a higher dose, possibly 1000-2000 UI /day. I got the cream, started using it and in a couple of days I've got the same digestive issues as when I am taking it orally. Stop the cream and problems go away in 24-36 hours. Start the D3 cream again and the problems come back again! I understand that oral D3 needs "processing" from the liver so that it is transformed into 25-Hydroxy-D3. Could it be that the liver is having a hard time processing it? So it doesn't matter whether it is taken orally or transdermally?