Just got my lab test and as usual my Hcy levels haven't moved a bit. I oscillate between 12.5 and 13.5 What is "interesting" is that when I started handling the problem of high Hcy ( very high at the time ) I didn't know I was MTHFR C677T+/+ and I was taking an active B complex with P5P (10mg), folic acid (400mcg) and Adeno-B12 (800mcg) prescribed by the doc. That helped bring the Hcy from 50+ down to --> 12.5 These days I take all the active Bs, no folic acid, 2000mcg Metafolin, 3mg Adeno-B12, 5mg Methyl-B12, 50mg P5P ... and Hcy levels are exactly the same. At least I would have expected even a minor improvement, especially after several months of therapy I am also dealing with major GI issues probably due to Blastocystis H. and very low bowel secretory IgA. I say "probably" because that's what emerged from a Great Plain Lab's test last year... they didn't find major dysbiotic flora, no yeasts, no malabsorption and inflammation markers are very low. If I didn't know those test results were mine I would have thought they belonged to someone who is relatively healthy, besides the blastocystis problem... I really don't match that kind of healthy profile, unfortunately. Many methylation experts state that bacterial/parasite infections can heavily tax the methylation cycle, so I suppose I fall in that category too. Problem is so far none of the cures to address the GI issues have produced any effect and I almost back to square one... Thoughts?