I have had this disease for many years, suffered through closed minded physicians and too many "specialists" to count who all denied this disease existence. Shen living in Nebraska I did have an excellent, amazing, pcp. An old school family and general practice doc with an open mind. He knew I researched everything and he even came up with some ideas that didn't pan out. But he knew something was wrong and that it was progressing. One day after several miserable weeks and months of debilitation I visited my doc. I had full body episodes of just not feeling well in general. I don't know why I thought this but I felt I had a general inflammation. He listened and ordered blood drawn for a SED rate.. Within minutes my blood work agreed with what we both felt. I did have inflammation. He continued SED testing and it was always positive. However last year I requested my new Washington PCP perform one and it came back negative. That may have been during a period of some remission. I have always developed fever blisters after fevers. I know something has been going on when a painful blister pops up. When my most recent very severe crash came on, I developed a fever blister. Suffering with hot flashes in summer brings on a blister. In summation, considering my history - I believe, at least in my case, inflammation is heavily involved. Someday soon I would like to share my 70 yr old medical history with a researcher.