I'm putting together a histamine receptor cheatsheet... I'm especially interested in histamine receptor 4 (H4)... Is there any supplement or drug besides culturelle (l rhamosus GG) that affects this receptor? eg downregulates it in order to reduce inflammation...
ps copied this out of evernote and the formatting is is weird.. sorry
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main source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697784/
ps copied this out of evernote and the formatting is is weird.. sorry
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main source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697784/
- Histamine H1 receptors: Smooth muscle and endothelial cells affecting skin & blood vessels
- effects: vascular permeability, bronchoconstriction, platelet aggregation
- counter effect agents: Benadryl, Claritin, Xyzal (levocetirizine) block activity of these receptors
- Histamine H2 receptors: Cells in the intestines control acid secretion, abdominal pain, and nausea; heart rate
- effects: heart rate & cardiac output; gastric secretion
- counter effect agents: Pepcid, Tagamet, Zantac
- Histamine H3 receptors: Central nervous system controlling nerves, sleep, appetite and behavior
- effects: neurotransmission
- counter effect agents: TBD
- Histamine H4 receptors: Thymus, small intestine, spleen, colon, bone marrow and white blood cells; inflammatory response
- effects: immunomodulation; chemotaxis; implicated in rheumatoid arthritis
- counter effect agents: culturelle (downregulates receptor, and, therefore inflammation) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042653/
- The Role of Histamine H4 Receptor in immune and Inflammatory disorders: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697784/
- Histamine H1/H2/H4 receptors:
- effects: chemokine & cytokine production (up AND down)
- Histamine H1/H2 receptors:
- effects: reduces blood brain barrier ( https://www.ncbi.nlm.nih.gov/pubmed/20956310 ; https://www.ncbi.nlm.nih.gov/pubmed/11450085 )
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