Hi everyone,
I'm just hoping for some advice / bounce ideas around with some knowledgable people, any input is welcome!
I've spent the last few days researching some test results I got recently - the tests found I have high S-adenosyl homocysteine (SAH), moderately high SAMe, low homocysteine and high glycine. The actual values are:
SAH: 37 nmol/L
SAMe: 140 nmol/L
Homocysteine: <2 umol/L (didn't specify an exact value, just less than 2)
Glycine: 424 umol/L
Methionine: 23 umol/L (normal but will discuss later)
I also had tetrahydrofolate, folinic acid and 5-methyl tetrahydrofalte tested, they were all within the normal ranges, values below:
Tetrahydrofolate: 4.8 nmol/L
Folinic acid: 25.0 nmol/L
5MTHF: 9.3 nmol/L
I also found I was heterozygous for MTHFR C677T, which may explain the slightly lowish 5MTHF.
Below is my interpretation of these results, I'd love to find out what others think.
I'm thinking there is an issue S-adenosylhomocysteine hydrolase (SAHH) enzyme (which I believe is coded for on the AHCY gene). This seems like it could explain the low homocysteine and high SAH & SAMe. Basically, my theory is that methylation is being inhibited by the buildup of SAH caused by the underactive SAHH enzyme, i think the underactive enzyme is also causing the deficit of homocysteine. It seems as though any homocysteine that is being made is being effectively recycled / or transsulfurated, so potentially there are no significant problems in those pathways.
I believe my methionine level is normal because I have been on a vegan diet for the past 2 years or so which would be low methionine, also low in creatine and choline which I think may now be causing me problems.
My tentative plan for treating improving this is:
Here's the passage from the study which discusses the treatment:
"The therapy included restricted methionine intake with supplementation of phosphatidylcholine, creatine and cysteine, which is a logical approach considering hypermethioninemia and possible inhibition of MTs, including PEMT. "
Any ideas or suggestions or anything are very welcome!
Thanks
I'm just hoping for some advice / bounce ideas around with some knowledgable people, any input is welcome!
I've spent the last few days researching some test results I got recently - the tests found I have high S-adenosyl homocysteine (SAH), moderately high SAMe, low homocysteine and high glycine. The actual values are:
SAH: 37 nmol/L
SAMe: 140 nmol/L
Homocysteine: <2 umol/L (didn't specify an exact value, just less than 2)
Glycine: 424 umol/L
Methionine: 23 umol/L (normal but will discuss later)
I also had tetrahydrofolate, folinic acid and 5-methyl tetrahydrofalte tested, they were all within the normal ranges, values below:
Tetrahydrofolate: 4.8 nmol/L
Folinic acid: 25.0 nmol/L
5MTHF: 9.3 nmol/L
I also found I was heterozygous for MTHFR C677T, which may explain the slightly lowish 5MTHF.
Below is my interpretation of these results, I'd love to find out what others think.
I'm thinking there is an issue S-adenosylhomocysteine hydrolase (SAHH) enzyme (which I believe is coded for on the AHCY gene). This seems like it could explain the low homocysteine and high SAH & SAMe. Basically, my theory is that methylation is being inhibited by the buildup of SAH caused by the underactive SAHH enzyme, i think the underactive enzyme is also causing the deficit of homocysteine. It seems as though any homocysteine that is being made is being effectively recycled / or transsulfurated, so potentially there are no significant problems in those pathways.
I believe my methionine level is normal because I have been on a vegan diet for the past 2 years or so which would be low methionine, also low in creatine and choline which I think may now be causing me problems.
My tentative plan for treating improving this is:
- ensure low methionine diet,
- supplement with creatine and phosphatidylcholine to ease pressure on the SAMe methylation donation stage, and
- take L-Cysteine to boost the transsulfuration pathway.
Here's the passage from the study which discusses the treatment:
"The therapy included restricted methionine intake with supplementation of phosphatidylcholine, creatine and cysteine, which is a logical approach considering hypermethioninemia and possible inhibition of MTs, including PEMT. "
Any ideas or suggestions or anything are very welcome!
Thanks