High methylmalonic acid (MMA) test result

[Lucas]

Hello.

I did the serum methylmalonic acid(MMA) test and it comes at 0,62 umol/L, Ref: 0,08 – 0,56.

So, my MMA is out of range.

Serum B12 comes at 997 pg/ml, without suplemention, and Homocysteine at 4,7 umol/L. Folic acid at 21,3 ng/ml.

Is this a diagnosis of active b12 deficiency?

I have Country Life, Methyl B12, 5000 mcg; Source Naturals, Dibencozide and methyl folate 400 mcg.

I started at 1 tablet of methylb12 and half of dibencozide and fell sleepy, tired. Is this normal at the beginning?

I had the MTHFR 677CT Hetero mutation.

My symptoms are:

- Fatigue

- Brain fog

- Depression

- Low body temperature

- Hair loss

- Tremors on head at day, legs and hands when sleeping

- Periodic movement limb disorder at sleeping

- No - Refreshing sleep

- Constipation

- Joint pain and weakness on legs

- Low stomach acid


These symptoms correlate to b12 deficiency?


How much methylb12 and adenob12 should I start to take?

Thank you very much!!

 

[pogoman]

Your symptoms correlate with B12 deficiency altho they are shared with many other diseases and syndromes so you may have more than one issue.

High MMA along with normal/high serum B12 levels may indicate a cellular B12 deficiency issue such as transcobalimin 2 deficiency.
Hydroxocobalamin B12 orally or injections are listed as a treatment so that may be better for you if your have bad reactions to methyl types.
Also, lithium orotate may help transfer serum B12 into cells.

http://ghr.nlm.nih.gov/condition/transcobalamin-deficiency
http://www.aafp.org/afp/2003/0301/p979.html

 

[Lucas]

Thanks’.

But since I don’t get anxious, insomnia, but fell tired and sleepy, this is a symptom of under methylation instead of over methylation?

 

[pogoman]

Have you talked to a doctor about your health issues?
Its possible other things like the mitochondrial or endocrine systems etc are subpar and B12 is not working very well.
But I would suggest talking to a doctor to see if other tests should be run, taking supplements blindly just gets expensive.