The 12th Invest in ME Research Conference June, 2017, Part 2
MEMum presents the second article in a series of three about the recent 12th Invest In ME International Conference (IIMEC12) in London.
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Hepatitis B, CMV and ME.

Discussion in 'General ME/CFS Discussion' started by jpcv, Mar 10, 2018.

  1. jpcv

    jpcv Senior Member

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    SE coast, Brazil
    Hi folks
    I have chronic Hep B infection, I discovered it in 1991 and I´ve been monitoring the disease since then.
    I have never developed any sign of active liver disease since the diagnosis and all my antibodies exams show that there is no active viral replication. My viral load is low.
    I got sick with ME almost three years ago and, like many people here, I have been submitted to all kind of tests and exams, and the results all came normal with the exception of an elevated ANA and high titres of IgG CMV .
    Some people here might know that Hep B infected patients can develop extra hepatic manifestations of the disease and lately my infectologist has been thinking about treating Hep B infection to see if there is any change in my ME evolution. I did an elastography that showed more liver fibrosis than expected for my viral load so now there is no excuse and I´m going to start an antiviral, Tenofovir.
    On top of that, there is the question of treating or not CMV . I know that the best antivirals for CMV are toxic for the liver so right now we don´t consider any kind of viral treatment.
    As soon as I start the drug, i´ll post my observations.
     
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  2. pattismith

    pattismith Senior Member

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    Hi @jpcv

    I have antibodies anti Hbs and anti HBc, so was just considered as carrier of a past infection.

    Are you positif with HBs antigen test?
     
  3. jpcv

    jpcv Senior Member

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    Yes, I´m Ag HBs positive and anti HBs negative
     
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  4. Hip

    Hip Senior Member

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    Tenofovir has been proving effective as a treatment for ME/CFS, and two ME/CFS doctors are now using this drug for ME/CFS. So with any luck, tenofovir might kill two birds with one stone.

    Some ME/CFS patients find they cannot tolerate full dose tenofovir to start with, and have to build up slowly to the full dose.
     
    Last edited: Mar 10, 2018
    pattismith likes this.
  5. pattismith

    pattismith Senior Member

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    It's worth tryig tenofovir I think!

    You mean that you antibodies anti HBs are negative?

    What frightens me a bit is that I am not allowed giving my blood because of my positive antibodies, even though they didn't find any Ag...So I wonder if this mean that the virus can reactivate any time?
     
  6. jpcv

    jpcv Senior Member

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    Yes, my antibodies are negative
    If your antigen is negative and your antibodies are positive it means that your imune system has cleared the vírus and you don´t have to worry about it.
     
    pattismith likes this.
  7. mariovitali

    mariovitali Senior Member

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    Last edited: Mar 14, 2018
    jpcv likes this.
  8. knackers323

    knackers323 Senior Member

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    Anyone have a good online source for tenofovir?
     
  9. Hip

    Hip Senior Member

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    See this post.
     
  10. jpcv

    jpcv Senior Member

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    Hi guys, I took my first dose of Tenofovir this morning.
    I hope it helps.
    I'll report later on side efects, clinical evolution,etc..
     
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  11. woodstock

    woodstock

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    So how is it going with the Tenofovir?
     
  12. knackers323

    knackers323 Senior Member

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    cfsers tend to get a worsening of symptoms on starting tenofovir or side effects? full dose is 300mg daily?

    i took my second 300mg today and had some mild stomach pains. may not be related
     
  13. Hip

    Hip Senior Member

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    I am not sure which, but I heard stores that some find they need to titrate up slowly to full a dose 300 mg.
     
  14. jpcv

    jpcv Senior Member

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    Tenofovir dose is 300 mg, i´ve been tolerating it quite well, no side effects so far.
    I´m feeling ok now, no crashes, but at the same time no major improvment .Regarding ME/CFS, I don´t expect major improvments in a few weeks of treatment.
    I´ll be returning to see my infectologist in May, she will probably ask me to repeat some tests like Hep B viral load to asses the eficacy of the drug.
     

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