I have COMT V158M and MAO-A R297R Homozygous +/+ Along with C677T and A1298C - Hetrozygous - +/- From what I understand is I don't breakdown neurotransmitters very well - "COMT and MAO are slow functioning". I started supplementing with (Methyl Folate, 400 mcg) and both methyl B12 and Active B12 Dibencozide about 4-5 months ago for the MTHFR mutations (I haven't found any noticeable difference day to day). I have periodic limb movements at night (PLMD) and I'm "wired and tired" all the time. I'm trying to fix my sleep as I feel this is one of the keys to everything else, from my research this could be low dopamine and/or inflammation. I have supplemented 5-htp 100mg and got quite a rush of feel good, didn't really help with sleep though. I've also supplemented 1000mg of GABA and that really chilled my legs out overnight but I still felt quite wired. I was about to try L-Dopa (as it has had good success with treating PLMD) but then I read up about dopamine in excess is actually causing problems in the brain. Short term fix but the cost of long term damage. I recently watched a video describing high amounts of dopamine can get funneled into a toxic pathway, I kind of agree with this in the way I feel, also I feel my serotonin levels are low/not balanced. (This is a gut feeling I have based on what I understand). Has anyone had any success treating these mutations, please share? I have the feeling I'm very low in these neurotransmitters, I would have thought I would have been high due to excess floating around? I've heard St Johns Wart is helpful for the COMT and MAO mutation. Is there anything else I can do to help support the COMT & MAO mutations? Thanks.