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Help with Methylation results?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Paul M, May 8, 2013.

  1. Paul M

    Paul M

    Boston, Massachusetts
    Sorry I'm a newbie here with this stuff, but am wondering what this means. I have Lyme Disease and have been on treatment for three months and am wondering if there is anything I can do with this information to help me further:

    MTHFR Mutations
    You have 1 heterozygous (yellow) mutation(s). These are generally not as bad as red homozygous mutation, but they may still worth paying attention to. They include:
    MTHFR A1298C is involved in converting 5-methylfolate (5MTHF) to tetrahydrofolate (THF). Unlike MTHFR C677T, the A1298C mutation does not lead to elevated homocysteine levels. This reaction helps generate BH4. BH4 is important in the detoxification of ammonia. The gene is compromised about 70% in MTHFR A1298C (+/+) individuals, and about 30% in people with a heterozygous (+/-) mutations.
    BH4 acts as a rate limiting factor for the production of neurotransmitters and catecholamines including serotonin, melatonin, dopamine, norepinephrine, and epinephrine. A MTHFR A1298C + status may cause a decrease in any of these neurotransmitters or catecholamines. It’s also a cofactor in the production of nitric oxide. If your BH4 cycle is not working effectively, you may experience mental/emotional and/or physical symptoms. Mercury, lead, and aluminum may act as a drain on BH4.
    Here are your homozygous mutations as indicated in your SNP gene table above (not including MTHFR):

    MAO-A R297R
    Here are your heterozygous mutations as indicated in your SNP gene table above (not including MTHFR):
    COMT V158M
    COMT H62H
    VDR Bsm
    VDR Taq
    MTRR A66G
    MTRR A664A
    CBS C699T
    CBS A360A
  2. Lotus97

    Lotus97 Senior Member

    United States
  3. caledonia


    Cincinnati, OH, USA
    I'm not sure about combining Lyme treatment with methylation treatment. However, if you do decide to do methylation, you'll likely have to treat CBS first.

    Watch my video Methylation Made Easy (link in my signature below) to get the basics.
  4. Lotus97

    Lotus97 Senior Member

    United States
    Rich and Dr. Nathan seemed to disagree on whether Lyme should be treated before doing methylation (although the article was from 2011 so Dr. Nathan might have changed his mind), but Rich thought methylation might be helpful for people with Lyme according what people have told me. Rich was actually going to speak at a Lyme conference about methylation which was held a few months after his passing. I think Dr. Nathan spoke on his behalf. In that thread I also posted a paper that Rich delivered at a Lyme conference in 2009. There's also some cautionary information about methylation. People with viral or bacterial infections could experience an increase in inflammation from methylation. Of course the Herxheimer reaction from antibiotics will also increase inflammation so there needs to be a balance with both treatments.

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