International ME/CFS and FM Awareness Day Is On May 12, 2018
Thomas Hennessy, Jr., selected May 12th to be our international awareness day back in 1992. He knew that May 12th had also been the birthday of Florence Nightingale. She was the English army nurse who helped to found the Red Cross as well as the first school of nursing in the world.
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Help with Methlyation Panel

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by loring, Jul 2, 2012.

  1. loring


    Hi - I have recently had a methlyation panel done. I've also done the 23andme testing. I'm working with an MD, but I wanted to post my results here with the hope of gaining a better understanding of what the heck is going on with my biochemistry.

    I've posted some 23andme results here:

    I reviewed the heartfixer documentation and I think I understand the basics, but I'm not sure that I completely understand my combinations.

    Methylation Panel Results (reference range):
    Glutathione (oxidised) 0.43 umol/L (0.16-0.50)
    Glutathoine (reduces) 2.5 umol/L (3.8 - 5.5)

    s-Adenosylmethoinine (RBC) 235 umol/L (221-256)
    s-AdenosylHomocystine (RBC) 48.8 umol/L (38.0-49.0)

    5-CH3-THF 8.8 nmol/L (8.4-72.6)
    10-Formyl-THF 3.7 nmol/L (1.5-8.2)
    5-Formyl-THF 4.20 nmol/L (1.20-11.70)
    THF 0.44 nmol/L (0.60 - 6.80)
    Folic Acid 10.2 nmol/L (8.9-24.5)
    Folinic Acid (WB) 8.5 nmol/L (9.0 - 35.5)
    Folic Acid, active (RBC) 294 nmol/L (400-1500)

    Adenosine 17.3 10^3 M (16.8-21.4)

    Can someone help me understand the results of this panel and how those relate to the genetic testing?

    I've started with supplements, but after the second day I feel very dizzy and nauseated.

    I get the sense from what I have read on the forum that feeling bad when starting out is not uncommon, but it there anything I can do to ease the initial transition? Or is it more of a "grin and bear it" situation?

    Here is how I'm getting my Bs & co-factors:
    UP Beta by Douglas Labs - 6 tabs
    Neurobiologix topical complex - 1 pump per day
    and 400 mcg of Folic Acid

    Thanks in advance for any insights.
  2. Lynn_M

    Lynn_M Senior Member

    Western Nebraska
    Your 23andMe test says you have 3 MTHFR mutations, which means folic acid does you no good. Yet you report freaky reactions to methylfolate. Have you tried calcium folinate (folinic acid)? People with A1298C can metabolize folinic acid.

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