Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
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Help with interpretation from Genetic Genie

Discussion in 'Genetic Testing and SNPs' started by Tanna78, May 7, 2016.

  1. Tanna78



    I'm looking for some help with the results of a 23andme test. I ran the data through several of the interpretation sites and am looking for any advice and suggestions that might aid a chronic anxiety disorder and severe depression that's resistant to treatment. I've been taking various meds and nothing seems to help, and I'm getting counselling with CBT? Both my partner and I feel that we are missing something as I had few health issues prior to my early 30s and was a very happy person.

    A little more history...

    Most recently my GP referred me to an endocrinologist (prior to the 23andme results being ready). The referral was made because despite my age (37), my bierd growth had slowed significantly over about 4 years and i had been resistant to treatment of depression and anxiety. The tests carried out were Testosterone (low-normal @8.5 - value typical of someone age 85), Estrogen (low), Lutenizing Hormone(low @1.9) and Follicle Stimulation Hormone (very abnormal @ 0.8), Cortisol 9am (normal), and Vitamin D (Sub-Optimal but in range). As the bierd growth slowed, my symptoms of anxiety and depression have increased. I've had my pituitary checked and nothing is evident on the MRI scan.

    I have also had Salivary cortisol and DHEA testing done and the curve was very normal. Hair mineral analysis also mostly normal. Only notable things on hair mineral were that the Na/Mg and Copper/Mg were slightly elevated ratios, likely because I've been taking Magnesium supplements to help my nerves. Been checked for Pyloria and result was ok.

    Wound healing is slow and healing tissue is evident for months or years which is different to before.

    Of note, I also spit pink or bloody sputum first thing in the morning and nobody in the medical profession seems to know why this is. It's not coughed up, just spit for a short time first thing each day.

    I'm taking Fish oils, Magnesium, Vitamin D 10k iu per day (for the past 5 weeks only and for another 3 at this level) and my antidepressant. Never been clinically depressed in my life before age 34, and not one to take medication without trying to heal without it first.

    Now to the DNA result run through Genetic Genie Methylation Profile Report.

    Homozygous :- (+/+)

    VDR Taq (rs731236) AA
    MAO-A R297R (rs6323) TT
    BHMT-08 (rs651852) AA

    Heterozygous :- (+/-)

    COMT V158M (rs44680) AG
    COMT H62H (rs4633) CT
    ACAT1-02 (rs3741049) AG
    MTRR A66G (rs1801394) AG
    MTRR K350A (rs162036) AG
    MTRR A664A (rs1802059) AG
    BHMT-02 (rs567754) CT
    CBS A360A (rs1801181) AG

    I have also posted a fuller version as an attachment.

    I'm looking for ways to aid with the significant depression and anxiety situation plus weight gain over 15 years that goes unexplained, and a sense of chronic fatigue and lethargy that I can't shift.

    Periodically I experience random remission of symptoms for several hours only. It does not relate to my thinking styles or change of circumstances.

    Specific support of the body through supplements or diet changes would be the sort of advice I seek. I've already tried Taurine, Inositol, Magnesium, B6 active form (P5P), zinc, fish oils, etc. Also any explanation for high cholesterol readings and liver issues too (I don't drink alcohol).

    If anyone can recommend a well qualified good naturopathic doctor in south east uk, this would also be welcomed.

    I've reached the lowest ebb in my life thus far, and a have lost more through this illness than I care to think about. Any pointer is going to help in some way!

    Many thanks for your thoughts and suggestions in advance.

    Matthew B x

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