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Help with 23andme results

Discussion in 'Genetic Testing and SNPs' started by OneWanders, Aug 24, 2014.

  1. OneWanders


    I got my methylation analysis from genetic genie but am really struggling to wade through the data.
    If anyone can point me in the right direction for more reading or advice I would really appreciate it, particularly for the homozygous mutations. I can find some info for the MAO one but hardly anything for the CBS mutation.
    Here they are:
    Here are your homozygous mutations as indicated in your SNP gene table above (not including MTHFR):

    • MAO-A R297R
    • CBS A360A
    Here are your heterozygous mutations as indicated in your SNP gene table above (not including MTHFR):

    • COMT V158M
    • COMT H62H
    • VDR Bsm
    • VDR Taq
    • MTR A2756G
    • MTRR A664A
    • BHMT-08
    I have OCD and depression amongst other issues so was wondering if anyone here has tried myo inositol with the MAO mutation.
    Thanks for any input :) Sorry to be such a newbie
  2. Critterina

    Critterina Senior Member

    Arizona, USA
    @OneWanders ,

    I don't think the homozygous mutations are ones that get treated, or if they do, I don't know about them. Personally, I wouldn't want to treat the MAO A if you are OCD and depressed. MAO A raises serotonin by slowing it's breakdown, and depression is usually too little serotonin.

    OCD and depression are often associated with MTHFR A1298C, and the recommended supplement is methylfolate. Are you sure you didn't miss that one when you were typing?

    There is also some mild/moderate effect on the methyl cycle from the MTR (not so much the MTRR) SNP, that B12 would exacerbate. Usually we want to supplement B12 in the methyl or hydroxy form, but not so much for you.

    Do you have high homocysteine? I would guess not. But if you do, I would favor the trimethyl glycine (TMG) over the B12, given your symptoms.

    As a newbie, you need to know that I am just one voice, and there are others, many of them more knowledgeable than me, and some that would probably take a different approach or disagree with me. I have no training in this area and I'm only putting the pieces together from what I read. Please consider multiple opinions, some preferably from an accredited or licensed health care professional, and take responsibility for your own choices. Above all, pay attention to how you feel and heed your body wisdom.

    victoriana likes this.
  3. Please read the SNPs Interpretation Guide linked in my signature links below this post.
  4. OneWanders


    Thanks so much for your response. This stuff seems so way over my head I don't know where to start! Genetic genie says I have no MTHFR mutations, and I just assumed that a MAO A mutation would mean not enough serotonin, not that I would have too much! How on earth can I have depression with too much serotonin?!
    How would I know if I have high homocysteine? To be honest, I was surprised had no MTHFR as that was the main reason I got tested. I do suffer from chronic migraine that has no apparent cause. Thanks again for your response :)
    victoriana likes this.

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