Help with 23andme Genetic Genie Interpretation

[danielle0090]

Hi everyone - I'm new to interpreting 23andMe results and would appreciate any help understanding the below in relation to ME/CFS. I'm homogeneous on quite a few and that worries me.

COMT V158M rs4680 AA +/+

COMT H62H rs4633 TT +/+

COMT P199P rs769224 GG -/-

VDR Bsm rs1544410 CT +/-

VDR Taq rs731236 AG +/-

MAO-A R297R rs6323 GG -/-

ACAT1-02 rs3741049 GG -/-

MTHFR C677T rs1801133 AG +/-

MTHFR 03 P39P rs2066470 GG -/-

MTHFR A1298C rs1801131 GT +/-

MTR A2756G rs1805087 AA -/-

MTRR A66G rs1801394 AG +/-

MTRR H595Y rs10380 CC -/-

MTRR K350A rs162036 AA -/-

MTRR R415T rs2287780 CC -/-

MTRR A664A rs1802059 AG +/-

BHMT-02 rs567754 TT +/+

BHMT-04 rs617219 CC +/+

BHMT-08 rs651852 TT +/+

AHCY-01 rs819147 CT +/-

AHCY-02 rs819134 AG +/-

AHCY-19 rs819171 CT +/-

CBS C699T rs234706 AG +/-

CBS A360A rs1801181 AG +/-

CBS N212N rs2298758 GG -/-

SHMT1 C1420T rs1979277 AA +/+

 

[sue la-la]

http://forums.phoenixrising.me/index.php?entries/caledonias-methylation-links.1744/

 

[Valentijn]

http://forums.phoenixrising.me/index.php?entries/caledonias-methylation-links.1744/

A lot of the stuff in @caledonia's guide is just repeating misinformation from elsewhere. Not a reliable source.

 

[Valentijn]

@danielle0090 - The only SNPs listed there which might result in potential problems are MTHFR C677T +/- and MTHFR A1298C +/-. Depending on whether or not you got both from the same parent, MTHFR enzyme function is approximately 65% or 30% of optimal. "Normal" is around 70% of optimal in the general population.

Studies looking into those mutations have primarily been regarding the increased risk of birth defects in the children of mothers with those mutations. In a couple of those studies, taking a normal amount of folate or folic acid from vegetables or multivitamins resulted in that increased risk disappearing. There is no indication that any of the SNPs listed above have any particular relevance to ME/CFS.

 

[Hope78]

Hi danielle, I am really a lay person in all this genetic stuff. But was I read is, that the
COMT V158M rs4680 AA +/+ polymorphism can make a person more prone to anxiety/stress and pain related problems. COMT brakes down catecholamines. In the ++ version the enzyme is slowed down. So dopamine and norepinephrine stay in the brain much longer. For "normal" individuals this can be an advantage. But for an already stressed out individual it can double the stress. There is also some research suggesting that comt++ individuals are more prone to "idiopathic" pain syndromes.
I am probably comt++ or +/-, too.
Good luck, hope this will help you!

 

[danielle0090]

@Valentijn @Hope78 Thank you both for your insights!