Hi! First post here, and would really appreciate some guidance in helping my daughter. Will try and keep the history brief! Long term history of food, animal and pollen allergies. The last three to four years has been a constant struggle for her health wise, catching every virus she encounters. In that time she has also battled terrible anxiety and now depression. She does not handle stress well and gets angry very easily. She is always exhausted. Wide awake at bed time and struggles through the day. No diagnosis at this point, doctors seem to think the sleep/exhaustion is all part of her anxiety and depression. Had nitrous oxide a few times last year for dental work and I do feel concerned that this has contributed, although she did seem to recover well from it at the time. She is a long way from the bright, happy, healthy and confident person she was before all this began. I discovered an article on undermethylators a while back, and it seems to fit her. We tried Folinic Acid because she does not consume a lot of folate foods. That ended with her in pain and very low mood wise (overmethylating?) I decided to run the raw DNA results we had from Ancestry through Nutra hacker. I know it is not the most reliable source and that is why I am here hoping someone will be able to help me work out which way to go. I have been trialling vitamins and we were doing ok until recently with B2, P5P and hydroxy B12. But the B2 and B12 together seemed to mess with her bowels. I added in a mineral supplement (without iron and copper), in case she needed iodine as there is a strong family history of hypothyroidism, it also has some potassium in it. She only took that and P5P while away for three weeks. Her energy levels have improved, but we also saw a return of the anxiety she seemed to be getting on top of. Her results from nutrahacker: Homozygous - MTRR (rs1802059), VDR (1544410), VDR (rs731236), SOD2 (rs4880 ), GSTP1 (rs1695), NAT2 (rs1208) and NAT2 (rs 1801280) Heterozygoes - CYP1A2 (rs 762551), COMT (rs4633), COMT (rs4680), MAO-A (rs6323), CBS (rs 1801181 and rs234706), MTHFR (rs1801131 and rs2066470), MTR (rs1805087) MTRR (rs1801394) and SHMT1 (rs1979277) It seems like so many, and I can't work out what is being expressed and making a difference and what isn't! I think she needs more folate, but am hesitant to give her that as she reacted poorly when she tried it. I am only using 1/4 to a 1/3 of each tablet/capsule/lozenge to try and avoid depleting other nutrients. If anyone can help me at all, I would really be grateful. She needs a break! Thank You.