Methylation: COMT V158M rs4680 AA +/+ COMT H62H rs4633 TT +/+ VDR Taq rs731236 AA +/+ MTRR A66G rs1801394 GG +/+ MTHFR C677T rs1801133 AG +/- MTHFR 03 P39P rs2066470 AG +/- MTHFR A1298C rs1801131 GT +/- MTRR A664A rs1802059 AG +/- BHMT-08 rs651852 CT +/- CBS A360A rs1801181 AA +/+ Detox: CYP1A2 164A>C rs762551 AC +/- CYP1B1 L432V rs1056836 GG +/+ CYP1B1 R48G rs10012 CC +/+ CYP2C9*2 C430T rs1799853 CT +/- CYP2D6 S486T rs1135840 CG +/- CYP2D6 100C>T rs1065852 AG +/- CYP3A4*1B rs2740574 CT +/- GSTP1 I105V rs1695 GG +/+ GSTP1 A114V rs1138272 TT +/+ SOD2 A16V rs4880 AG +/- NAT2 R197Q rs1799930 AA +/+ All I know is he can't take methyl donors... Our experience matches Yasko's clinical observations. The Genetic Genie report seems to be spot on. Low tolerance to sulfur foods, high need for BH4 (royal jelly already on board). Roadblock: no HyB12 available locally (only for IM), so we will have to order it online. He apparently tolerates well CyB12, and I suppose he could take a low dose of it while we wait for the HyB12 delivery. The best he felt this year was upon drinking his 1st can of Red Bull... Not a repeatable experience though. And I don't think he would tolerate such high amounts of taurine on a long term. Also I don't think magnesium glycinate is the best form for him. But it was what I had at home, and he took it for a while and hasn't taken a NSAID for over a month He suffered several years with sciatica/herniated disk - his dr. even suspected ankylosing spondylitis. He had surgery of the ulnar nerve compression, is on SSRI and his circadian rhytim is out of order. Mercury is involved, and he has been bitten by tick larvae in 2003 with me. I will be very thankful for tips from anyone with similar SNPs and insights from more experienced members.