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Help me make sense of my GPL-MycoTOX results!

Discussion in 'Addressing Biotoxin, Chemical & Food Sensitivities' started by used_to_race, May 17, 2018.

  1. used_to_race


    A few weeks ago, I sent in a sample to GPL for their mycotoxin panel. My results came back the other day, and they are as follows (all units in ng/g creatinine):

    Metabolite ------- Result ------- Common Range of Positive Results
    Aflatoxin M1 (AFM1) ------- 0 ------- 1.3-3
    Ochratoxin A (OTA) ------- 48.4 ------- 1.2-5
    Sterigmatocystin (STG) ------- 0 ------- 0.1-2.25
    Roridin E ------- 0 ------- 0.5-2
    Verrucarin A ------- 0 ------- 0.75-2.25
    Enniatin B1 ------- 0 ------- 0.5-1.2
    Zearalenone (ZEA) ------- 0 ------- 0.09-0.45

    So as far as I can tell, this is just a measure of the excretion of any of these toxins/metabolites at the moment the sample was collected. These have an apparently long half-life in the body, so the instantaneous excretion is probably a good indicator of exposure over the month or so preceding the sample collection. Is this a fair summary?

    If that's the case, I see no reason why any particular value is necessarily of clinical significance, despite GPL saying that all positive values are clinically significant. As far as I know, the problem with mold exposure (and CIRS) is not the excretion of the toxin, but rather the lack of one's ability to excrete the toxin. Is this correct? If so, then excretion could be a good thing (albeit suggestive of continued exposure, which is a bad thing), right?

    If this test is proof of exposure, which testing can I do to see if this exposure is problematic in my case? I have had labs drawn for:

    • ADH (Antidiuretic Hormone) - apparently low in cases of mold toxicity. I myself urinate very frequently.
    • HLA-DR by PCR - genetic testing that predicts inability to process certain mycotoxins.
    • MSH (Melanocyte Stimulating Hormone) - apparently low in cases of mold toxicity. Can affect immune function.
    • VIP (Vasoactive Intestinal Peptide) - another hormone that is commonly low in cases of mold toxicity.
    • TGF-beta 1 - cytokine that is often elevated in cases of mold toxicity.
    • Serum Osmolality - apparently low in cases of mold toxicity.
    • VEGF - I think this is a cytokine (?) or some other protein that is apparently high in cases of mold toxicity.
    • Prothrombin/Antithrombin
    I'll follow up with the results here in this thread, and hopefully someone will discuss these with me. Are there any others I should do? I know that C3a and C4a are commonly looked at in CIRS. I had this test done by my rheumatologist a month or two ago. Are the C3 and C4 complements in this panel the same thing as C3a and C4a? My values were at the low end of the normal range for each.

    Additionally, I have taken a VCS test online and scored 100%.

    Depending on the results of these other tests, I will probably get an ERMI kit and have my living room tested, or maybe even several rooms in my apartment. There's no obvious mold problem in my apartment or office, so maybe the source of the ochratoxin A is from food. But because the amount excreted is so high, I can't imagine that all this OTA would be coming from food...

    I can talk about my symptoms if anyone is interested, but basically I have mild CFS-like symptoms for 2-3 years now, sudden viral onset with a couple periods of brief remission towards the beginning. Constant sore throat, mild runny nose, lymphadenopathy, periodic mild POTS/palpitations, frequent urination, cold intolerance. Very limited, even nonexistent cognitive dysfunction. No pain or light/sound sensitivity. Anyone have any thoughts?

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