Sushi
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Gut microbiota: Microbiota and neuroimmune signalling—Metchnikoff to microglia
- Thread starter Sushi
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shannah
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Research from Ireland. Unusual.
Ema
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Here's a penny summary of the summary:
Basically they have discovered through studies of germ free mice, that the gut microflora influences the maturation, number, shape and response of the microglia by influencing a number of different genes.
They checked this by giving normal adult mice an antibiotic cocktail that decimated their intestinal flora and those mice started demonstrating the same features of the microglia as the germ free mice.
Those effects were able to be reversed when they repopulated their gut flora.
Then it talks about what components of the microbiome are responsible for these effects and it mentions short chain fatty acids (sodium butyrate, sodium propionate and sodium acetate) in particular even though no receptors have been found in the brain yet.
This process of the microbiota influencing the microglial cells is crucial during development but also persists into adulthood. And so studying this further should provide interesting avenues for treatment of various disorders.
Basically they have discovered through studies of germ free mice, that the gut microflora influences the maturation, number, shape and response of the microglia by influencing a number of different genes.
They checked this by giving normal adult mice an antibiotic cocktail that decimated their intestinal flora and those mice started demonstrating the same features of the microglia as the germ free mice.
Those effects were able to be reversed when they repopulated their gut flora.
Then it talks about what components of the microbiome are responsible for these effects and it mentions short chain fatty acids (sodium butyrate, sodium propionate and sodium acetate) in particular even though no receptors have been found in the brain yet.
This process of the microbiota influencing the microglial cells is crucial during development but also persists into adulthood. And so studying this further should provide interesting avenues for treatment of various disorders.
Sushi
Moderation Resource Albuquerque
- Messages
- 19,935
- Location
- Albuquerque
Remember the discovery of meningeal lymphatic vessels which connect the brain and immune system? That would seem to tie in.
This article also makes clear that there is two way communication that is essential for brain health and that the microglia -- which are the brain's macrophages--are affected by the composition of the microbiota.
This article also makes clear that there is two way communication that is essential for brain health and that the microglia -- which are the brain's macrophages--are affected by the composition of the microbiota.
Not really. University College Cork is one of the main academic centres in the world doing microbiome research.