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Gluten may cause depression in subjects with non-c gluten sensitivity

Discussion in 'Other Health News and Research' started by natasa778, Apr 6, 2014.

  1. natasa778

    natasa778 Senior Member

    Randomised clinical trial: gluten may cause depression in subjects with non-coeliac gluten sensitivity – an exploratory randomised clinical study

    Interesting discussion as to why this could be happening:

  2. Wayne

    Wayne Senior Member

    Ashland, Oregon
    The book "Grain Brain" is comprehensive and easy read. --- Describes the high prevalence of "gluten sensitivity", and how it majorly impacts the body, especially the brain. This can occur even when there are NO indications of Celiac Disease, and can be even MORE serious than CD.

    --- by Dr. David Perlmutter

    Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

    --- This online article is a good read as well:

    The Dark Side of Wheat - New Perspectives On Celiac Disease and Wheat Intolerance - by Sayer Ji
    Last edited: Aug 24, 2014
    xchocoholic and Helen like this.
  3. Hip

    Hip Senior Member

    This is very interesting. I suffered from gluten-induced depression all my life. Whenever I eat gluten, after around an hour, significant depression hits me, and this depression last for around 8 hours before subsiding. I don't get any other symptoms from eating gluten, just depression. This arrival of depression in me would occur like clockwork as soon as I ate gluten.

    The odd thing, though, is that since getting ME/CFS, I no longer get depressed by eating gluten. So whatever the mechanism by which gluten triggers depression, somehow the changes that occur in ME/CFS have arrested that mechanism.

    If it is exorphins — the opioid peptides derived gluten — that are causing the gluten-induced depression, then since ME/CFS patients have altered beta endorphin levels, this might explain why my ME/CFS abolished my gluten-induced depression.

    Another possible mechanism for the cause of gluten-induced depression — one that is not mentioned in the above papers — is depression arising from the immune activation that gluten can cause in the intestines of some sensitive people (new studies show that immune activation may underpin depression).

    I read some very interesting research by Dr Alessio Fasano, who has investigated the difference between gluten sensitivity in those with celiac disease, and non-celiac gluten sensitivity.

    It turns out that in non-celiac gluten sensitivity, the innate immune system targets and attacks the gluten in the intestines, leading to inflammation both inside and outside the digestive system. Whereas in celiac gluten sensitivity, this immune attack involves both the innate immune system and the adaptive immune system responding to gluten.

    It is the adaptive immune system that is behind autoimmune disease, and in celiac disease, gluten causes the adaptive immune system to mount an autoimmune attack on the intestines, leading to intestinal damage (specifically, destruction of the villi of the small intestine).

    In non-celiac gluten sensitivity, because the adaptive immune system is not involved, there is no intestinal damage. Although Dr Fasano says non-celiac gluten sensitivity can produce near-identical symptoms to celiac, including diarrhea, bloating, abdominal pain, joint pain, depression, brain fog and migraines.
    natasa778, Valentijn and Wayne like this.
  4. Wayne

    Wayne Senior Member

    Ashland, Oregon
    The following is from Dr. David Perlmutter's Website:

    Gluten Containing Products
    If experiencing gluten intolerance symptoms, the products on this page should be avoided. Instead, concentrate on gluten free, brain healthy foods. Many are listed here. This is sure to help maintain or improve brain health and function.

    The following grains and starches contain gluten:
    • Wheat
    • Wheat germ
    • Rye
    • Barley
    • Bulgur
    • Couscous
    • Farina
    • Graham flour
    • Kamut Matzo
    • Semolina
    • Spelt
    • Triticale
    The following foods often contain gluten:
    • malt/malt flavoring
    • soups
    • commercial bullion and broths
    • cold cuts
    • French fries (often dusted with flour before freezing)
    • processed cheese (e.g., Velveeta)
    • mayonnaise
    • ketchup
    • malt vinegar
    • soy sauce and teriyaki sauces
    • salad dressings
    • imitation crab meat, bacon, etc
    • egg substitute
    • tabbouleh
    • sausage
    • non-dairy creamer
    • fried vegetables/tempura
    • gravy
    • marinades
    • canned baked beans
    • cereals
    • commercially prepared chocolate milk
    • breaded foods
    • fruit fillings and puddings
    • hot dogs
    • ice cream
    • root beer
    • energy bars
    • trail mix
    • syrups
    • seitan
    • wheatgrass
    • instant hot drinks
    • flavored coffees and teas blue cheeses
    • vodka
    • wine coolers
    • meatballs, meatloaf communion wafers
    • veggie burgers
    • roasted nuts
    • beer
    • oats (unless certified GF)
    • oat bran (unless certified GF)
    The following are miscellaneous sources of gluten:
    • shampoos
    • cosmetics
    • lipsticks, lip balm
    • Play-Doh
    • medications
    • non self-adhesive stamps and envelopes
    • vitamins and supplements (check label)
    The following ingredients are often code for gluten:
    • Avena sativa Cyclodextrin
    • Dextrin
    • Fermented grain extract
    • Hordeum distichon
    • Hordeum vulgare
    • Hydrolysate
    • Hydrolyzed malt extract
    • Hydrolyzed vegetable protein
    • Maltodextrin
    • Phytosphingosine extract
    • Samino peptide complex
    • Secale cereale
    • Triticum aestivum
    • Triticum vulgare
    • Tocopherol/vitamin E
    • Yeast extract
    • Natural flavoring
    • Brown rice syrup
    • Modified food starch
    • Hydrolyzed vegetable protein (HVP)
    • Hydrolyzed soy protein
    • Caramel color (frequently made from barley)
    You can get tested for gluten sensitivity using a Cyrex array 3 test. More information about the Cyrex test can be found at the Cyrex website.
    SickOfSickness likes this.

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