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Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome

Discussion in 'Latest ME/CFS Research' started by Cheesus, Jan 29, 2017.

  1. Cheesus

    Cheesus Senior Member



    The role of pathogen specific cellular immune responses against the eliciting pathogen in development of post-infectious chronic fatigue syndrome (PI-CFS) is not known and such studies are difficult to perform. The aim of this study was to evaluate specific anti-Giardia cellular immunity in cases that developed CFS after Giardia infection compared to cases that recovered well. Patients reporting chronic fatigue in a questionnaire study three years after a Giardia outbreak were clinically evaluated five years after the outbreak and grouped according to Fukuda criteria for CFS and idiopathic chronic fatigue. Giardia specific immune responses were evaluated in 39 of these patients by proliferation assay, T cell activation and cytokine release analysis. 20 Giardia exposed non-fatigued individuals and 10 healthy unexposed individuals were recruited as controls.

    Patients were clinically classified into CFS (n = 15), idiopathic chronic fatigue (n = 5), fatigue from other causes (n = 9) and recovered from fatigue (n = 10). There were statistically significant antigen specific differences between these Giardia exposed groups and unexposed controls. However, we did not find differences between the Giardia exposed fatigue classification groups with regard to CD4 T cell activation, proliferation or cytokine levels in 6 days cultured PBMCs. Interestingly, sCD40L was increased in patients with PI-CFS and other persons with fatigue after Giardia infection compared to the non-fatigued group, and correlated well with fatigue levels at the time of sampling.

    Our data show antigen specific cellular immune responses in the groups previously exposed to Giardia and increased sCD40L in fatigued patients.

    Full text: https://bmcimmunol.biomedcentral.com/articles/10.1186/s12865-017-0190-3
    Valentijn, Hutan, Chocolove and 4 others like this.
  2. Kalliope

    Kalliope Senior Member

    This has been performed at the same hospital where Fluge/Mella works. There was an outbreak of Giardia in Bergen some years ago from contaminated drinking water. Quite a few got sick, some with ME.

    The silver lining has been an increased interest in chronic fatigue and ME from Haukeland University hospital.
    mango, Valentijn, Solstice and 6 others like this.
  3. mfairma

    mfairma Senior Member

    I fell sick following protracted infection with giardia. I've always felt, however, that the antibiotics used to treat were likely more responsible, as I had sudden onset two weeks after the second course of antibiotics prescribed, which was metronidazole. I've read since from others with different infections who feel that the same drug played a role in their onset. I would be curious to know whether they considered the antibiotics used to treat.
    ljimbo423 likes this.
  4. Snow Leopard

    Snow Leopard Hibernating

    South Australia
    This suggests that the post-giardiasis CFS is unlikely to be due to chronic infection. The T-cell findings do not rule out autoimmunity (most autoimmune diseases do not require altered T-Cell functioning) or other immune disturbances.

    Interestingly, elevated soluble CD40 ligand is associated with some rheumatic autoimmune illnesses.
    Hutan likes this.

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