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Genova diagnostics energy cycle test results

Discussion in 'Genetic Testing and SNPs' started by bostjan01, Jan 18, 2018.

  1. bostjan01


    I've had CFS for 7 years my worst symptom is severe brain fog and fatigue. I've had test ION test with 40 amino acids test done and it revealed dysfunction in energy cycle metabolism. I have elevated Pyruvate which should, if I understand correctly, turn into Acetyl CoA which should metabolize into Citrate which is low.

    I'm wondering if anyone else with CFS also had this test done and has similar results? What do you think would be solution?

    I've attached part of test which shows energy cycle and also whole test if you want to check.

    Attached Files:

    Runner5 likes this.
  2. Runner5

    Runner5 Senior Member

    That high level of Arsenic would concern me the most I think...
  3. matt321


    All you are looking at is bio markers of a stressed system. There isn't much meaning you can derive from the results. Try following the recommendations they give, but this doesn't show causality unfortunately.
  4. caledonia


    Cincinnati, OH, USA
    You can somewhat interpret that test with the NutrEval Interpretation Guide (in my signature link).

    If you look at the energy cycle diagram on the sample report (page 7) it shows what co-factors are needed, and what the inhibitors are.

    Hint - inhibitors are mercury, arsenic, antimony and fluoride.

    Your test is showing high in arsenic. I assume it was not a provoked test, so that means you have a current exposure of arsenic. It could be water or food such as rice or rice products.

    You could also have mercury or other metals, but not a current exposure. The toxic metals bioaccumulate in your tissues, bones and brain, causing many issues in multiple body systems. They all cause fatigue.

    There are many ways to detect metals and chelate them out, some are better or safer than others. See the Chelation section in my signature link for more info on the method I've found to be the best for me.
  5. bostjan01


    I tried detoxing with chlorella and zeolite. I'm also thinking of trying glutathione but wonder how well it's absorbed.
  6. nanonug

    nanonug Senior Member

    Virginia, USA
    Highish pyruvate with lowish citrate to me suggest a problem in the pyruvate dehydrogenase complex. This is consistent with findings by Naviaux regarding subjects with SEID. If these results applied to me, I'd start by taking a good Complex B supplement (preferably with the activated forms such as methylcobalamin and methylfolate), together with chelated magnesium and a few hundred milligrams a day of fursultiamine (emphasis on few hundred milligrams a day of fursultiamine). Today I posted something that might be of interest to you: From brain fog to clarity in 30 minutes. Caveat: this is what I would do if these results applied to me. I'm in no way, shape or form recommending these for you. That should be strictly your decision.

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