Hi All, I've been "living" with Fibromyalgia, ME/CFS, Hashimoto's, PCOS & adrenal insufficiency for years now. I was very healthy as a child. Problems initially started with puberty. I developed PCOS, hormone issues & accompanying depression. I was put on the pill. In mid-teens, I did catch Mono & a bad staph infection in my bloodstream. After that (not sure which one), I would have bouts of waking up with swollen glands in my throat and feeling sick, which would go away by the next day. Otherwise, I was fine. Then at 20, after a major emotional upset followed two weeks later by a still-undiagnosed illness (fever, bed-bound for over a week) I suddenly started putting on weight. I put on around 40lbs in 5 months with no change in diet or activity. I had never had weight problems in my entire life. A year after the emotional upset and illness I started noticing I had no energy and had some joint pain. Not normal at 21! Over the years I just continued to slowly degrade. Doctors blew me off & my then husband said I was a hypochondriac. I ended up believing them. I had a child at 23. I felt SO GOOD during my pregnancy! I had energy and felt great. I now suspect it was the higher levels of progesterone, which I later found out I don't make enough of (hormone pathway goes direction of adrenal hormones instead). Over the years, more weight...more fatigue. At 33 I was "accidentally" diagnosed with Hashimoto's and began thyroid replacement. A few years later, the fibromyalgia pain set in and then the chronic fatigue just seemed to get worse. I started having sleep issues (insomnia and/or feeling exhausted even after full night's sleep). The joint and muscle pain also worsened. I had to quit working. A few years later, my adrenals almost stop functioning. Very scary time. I was placed on replacement cortisol, which I still have to take. During all of this, I was fighting hard to make sure my daughter didn't develop what I had. My mother had PCOS & accompanying mood issues. My daughter was also very healthy UNTIL PUBERTY. Once that happened, she started gaining weight...started having bad depression & mood issues....never had normal cycles. She went on bio-identical progesterone like me, which helped. However, she was never "normal". By her late teens, her thyroid hormones were low (non-Hashimoto's). She went on thyroid replacement. Flash forward to this last spring. It is her final semester in college. She calls me one day very scared. She is dizzy, almost passing out (vision going black), feels 'disconnected' emotionally, has memory & cognitive issues and feels awful. The doctor does tests and her adrenals are not functioning well now. She has to go on replacement cortisol and salt water (low aldosterone). She had to fight hard her last semester to be able to graduate, and now has been apartment bound since May trying to "heal" her adrenals so she can work. She is only 23!!! I am scared to DEATH she will continue down my path and end up like all of us...with Fibro, ME/CFS, etc. I am now convinced that this is genetic in our cases. I see it now with problems my Mother had, what I've had and now in my daughter. She went down the EXACT same path as me, only hers seems accelerated. Has anyone here gone through this pattern? Or know of any doctors that are versed in this (genetic cause of HPA axis dysfunction) or at least studying it? I need to find a treatment for her so she can go live her life and not end up like me. Any help is GREATLY APPRECIATED!!! Thank you! P.S. I (we) have not yet done the 23andme testing, but do plan to.