General Anesthesia & Sensitivity to Medications

[joejack102]

For all those with CFS/ME/POTS/etc etc,

1) Are you particularly hyper-sensitive to the effects of medications?

2) Have you undergone full anesthesia? If so, did you respond abnormally?

 

[Diwi9]

1) Since having ME/CFS, stimulants (including coffee) increase brain fog and can induce a crash.

2) I have had problems getting numbed at the dentist when getting fillings, with removal of my wisdom teeth, and during a root canal. I have never had a problem with anesthesia during surgery (I don't know if it was "full" anesthesia, I seem to remember the term "twilight" anesthesia being mentioned both times). I now pay extra for IV sedation during dental work after too many painful experiences.

 

[Binkie4]

http://forums.phoenixrising.me/index.php?threads/reaction-to-local-anaesthetic.53282/

There is currently a thread on anaesthetic reaction on above thread. Perhaps they should be combined?

 

[Diwi9]

http://forums.phoenixrising.me/index.php?threads/reaction-to-local-anaesthetic.53282/

There is currently a thread on anaesthetic reaction on above thread. Perhaps they should be combined?

I just saw that thread after I posted my experience at the dentist above. Did not realize that others had problems with local anesthetic as well. Crazy stuff...

 

[joejack102]

http://forums.phoenixrising.me/index.php?threads/reaction-to-local-anaesthetic.53282/

There is currently a thread on anaesthetic reaction on above thread. Perhaps they should be combined?

Local anesthetic and full general anesthesia are very different.

 

[Binkie4]

@joejack
Thanks Joejack. I am ok with local anaesthesia without adrenaline. Have never had a GA since having ME which is why I am concerned.

 

[Hanna]

I had a general anaesthesia in 2002 and my heart reacted so badly to it that I was 1 month in cardio rehabilitation. Name of the stuff was PROPOFOL.
I learnt later that propofol is toxic to mitochondria, so beware.

 

[Binkie4]

@Hanna
@Sushi very kindly provided me with some links to details of types of anaesthesia recommended. Cheney' s article referred to a Dr Glass, very experienced in anaesthetising ME patients, and he recommended propofol! Really difficult.
Thank you for replying anyway. I suspect we may all be different. I think I need to talk to the anaesthetist, give any info I have to him and let him take over.



EDIT: Charles Lapp's leaflet on anaesthesia also recommends propofol as well tolerated in ME.

 

[Hanna]

A Rare Case of Propofol-Induced Acute Liver Failure and Literature Review
G. Kneiseler,a H.S. Bachmann,b L.P. Bechmann,a A. Dechene,a T. Heyer,e H. Baba,c F. Saner,d C. Jochum,a G. Gerken,a and A. Canbaya,*
Author information ► Copyright and License information ►

This article has been cited by other articles in PMC.


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Abstract
The incidence of drug-induced acute liver failure is increasing. A number of drugs can inhibit mitochondrial functions, alter β-oxidation and cause accumulation of free fatty acids within the hepatocytes. This may result in hepatic steatosis, cell death and liver injury. In our case, propofol, an anesthetic drug commonly used in adults and children, is suspected to have induced disturbance of the mitochondrial respiratory chain, which in consequence led to insufficient energy supply and finally liver failure. We report the case of a 35-year-old Caucasian woman with acute liver failure after anesthesia for stripping of varicose veins.

@Binkie4 , yes we all react differently. And it seems that those reactions are rare.