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Gastric Enterovirus Infection: A Possible Causative Etiology of Gastroparesis

Discussion in 'Other Health News and Research' started by Kyla, Jul 2, 2016.

  1. Kyla

    Kyla ᴀɴɴɪᴇ ɢꜱᴀᴍᴩᴇʟ

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    http://www.ncbi.nlm.nih.gov/pubmed/27344315

    Though this is a study on idiopathic gastroparesis it looks like half the patients had an ME/CfS diagnosis (I included the relevant passage below the abstract).




     
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  2. Hip

    Hip Senior Member

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    Very interesting, especially that half the patients given antiviral treatments had improvements in their gastroparesis (delayed gastric emptying). Although the antiviral treatments were somewhat hotchpotch. The full paper details the antiviral treatments received:
     
  3. kangaSue

    kangaSue Senior Member

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    Dr Chia was of a similar opinion in a study into those both with and without ME/CFS

    http://file.scirp.org/pdf/OJGas_2015040916050357.pdf

    [In summary, our studies provided evidence for the pathogenic role of enteroviral dsRNA in the stomach biopsies of patients who had FD/chronic gastritis with and without ME/CFS. Much more research will be needed to define the mechanism of virus-mediated tissue injury and host responses. Development of antiviral therapy against enteroviruses and/or dsRNA cannot be overemphasized, and the importance of enteroviruses in FD/chronic gastritis can only be realized with a randomized, placebo-controlled antiviral drug trial.
     
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  4. Justin30

    Justin30 Senior Member

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    With all the talk stemming back 70 years about EV. Is seems this area of research is so in need of further research eapecially in ME/CFS.

    This being said we know the EV Polio and the devestation it could cause why not other EVs?
     
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  5. kangaSue

    kangaSue Senior Member

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  6. kangaSue

    kangaSue Senior Member

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    Seems the same similarities have thought to apply Type 1 Diabetes for a while too.

    http://diabetes.diabetesjournals.org/content/61/3/687
    [Enterovirus RNA was found in diabetic patients more frequently than in control subjects and was associated with a clear inflammation response in the gut mucosa. Viral RNA was often detected in the absence of viral protein, suggesting defective replication of the virus. Patients remained virus positive in follow-up samples taken after 12 months’ observation. The results suggest that a large proportion of type 1 diabetic patients have prolonged/persistent enterovirus infection associated with an inflammation process in gut mucosa. This finding opens new opportunities for studying the viral etiology of type 1 diabetes.]
     
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  7. jepps

    jepps Senior Member

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    Association between Crohns Disease and enterovirus is also described in this thread: http://forums.phoenixrising.me/index.php?threads/link-shown-between-crohns-disease-and-virus.23979/

    Interesting is this:

    because enterovirus in the nervs occupying receptors in the nerv cells could change the function of signaling molecules, and therefore create chronic inflammation.
     
    Last edited: Jul 10, 2016
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  8. Hip

    Hip Senior Member

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    Have you ever ventured to try any anti-enterovirus treatments, @kangaSue, on the assumption that your gastroparesis may be due to enterovirus?

    Oxymatrine / Equilibrant might be worth looking into, as that's Dr Chia's most effective enterovirus treatment; I actually tried oxymatrine speculatively for my ME/CFS even before I was able to get a blood test to confirm I had chronic enterovirus. This you can buy online as a supplement.

    Dr Chia also uses Epivir, which he finds produces mild benefits in around 1 in 3 enterovirus ME/CFS patients.

    Ribavirin is a more potent enterovirus antiviral, but long term use is inadvisable because of toxicity.

    More recently Chia has been trying tenofovir, and antiviral and immunomodulator.

    I was looking into interferon alpha suppositories to treat enterovirus. Dr Chia used IV interferon for ME/CFS patients with some success, but Western IV interferon is very expensive, around $5000 per month. However, for around $10 you can buy cheap Russian interferon alpha suppositories.

    See this post for more info on cheap Russian interferon alpha suppositories. I briefly tried some low dose interferon alpha suppositories (around 15,000 IU daily), and they seemed to reduce my bowel viral symptoms (ever since I first caught my ME/CFS virus, it caused chronic odorless bowel gas production, ie flatulence, but the low dose interferon seemed to improve this).
     
    Last edited: Feb 11, 2018
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  9. kangaSue

    kangaSue Senior Member

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    I've been on a different track of late as to the cause of my gastroparesis after discovering for myself that some of my imaging studies were clearly showing Nutcracker Syndrome (NCS - left renal vein compression) but it was missed by all the supposed medical professionals.

    It's a long story but about 20% of those with this have severe autonomic dysfunction (in having POTS) and plenty of others have a lesser involvement with low bp, GI problems and Autonomic Neuropathy, with or without the more typical other symptoms of NCS, which fits for me, and fixing the renal vein compression is also relieving these other symptoms in many cases.

    I don't identify as having ME/CFS but interestingly, I have come across a numer of people in other forums who eventually found that they had NCS after first being diagnosed with ME/CFS instead.

    I gave up on pursuing an enterovirus cause when repeated pleas to my GI to do some full thickness biopsies of the GI tract fell on deaf ears. I was hoping to send samples off to the Enterovirus Foundation for testing but because they found intestinal ischemia damage during a colonoscopy (and it resulted in having a perforated bowel from the scope), I was deemed too high a risk to have any biopsies taken in future, either the standard variety or full thickness one's.

    For the same reason, they now won't contemplate doing the major surgery required to fix the renal vein compression either. Everyone is quoting their favourite mantra and "get out" clause at me, "first, do no harm." As you can imagine, that approach is not doing much to alleviate my symptoms!
     
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  10. Hip

    Hip Senior Member

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    I wonder if enterovirus blood tests would show elevated antibody titers in patients with enterovirus-associated gastroparesis? Dr Chia finds many enterovirus ME/CFS patients have raised antibody titers.

    It's only the antibody test by the neutralization method (rather than antibody tests by ELISA, IFA or CFT) that Dr Chia found are sensitive enough to detect chronic enterovirus.
     
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