Hi! A few days ago I got my 23andme reports back. I am especially interested in the enzyme that is converting glutamine/glutamate into GABA. The only drugs I ever responded to in a positive way (no more anxiety, less pain, no insomnia) were gaba-ergic drugs like antiepileptics and benzodiazepines. I became very senstive to every medication, so that's no option any longer beside the fact that I don't want to be dependend on benzos. I also do NOT respond positively to the GABA supplement (capsules). So my doctor suggested to give l-glutamine a try but his concern is about stimulating the NMDA-receptors rather than converting it into GABA via the GAD-enzyme. I have 9 versions of the GAD1 enzyme, unfortunately promethase is not telling me weather it's the normal or the slow version of the enzyme. I have 3 homozygous versions, two of it rare and hetero versions. So it's rs2241165(G;G) (Frequency 2,7%) 1 rs3749034(T;T) (2,7%) 2 rs3828275(G;G) 3 rs2058725(A;G) 4 rs3791851(A;G) 5 rs769407(C;G) 6 rs3791878(C;C) 7 rs12185692(C;C) 8 rs3791850(A;G) Most oft them are tagged with anxiety disorder & depression. Does anyone know about it? I am also homoc. for MAO-A and hetero for COMT, so I guess that could be the reason why normal antidepressants did noting for me instead (some of them actually worsened my condition) Thank you!