I would appreciate some help from Freddd or someone with knowledge of his protocol. I've been doing Freddd's protocol for a number of months and thought I was being successful. I've felt so much better. Anxiety way down, fatigue way down, energy up. I don't have diagnosed chronic fatigue but was exhausted and had severe anxiety. I am heterozygous for 3 MTHFR genes. (Have a Genetic Genie report of all the other stuff). I've been increasing folate as symptoms seemed to dictate and am at 9,600mcg. I had been at about 3,000mcg for some time, but ended up with this significant increase last month due to angular cheilitis. Any drop seems to cause angular cheilitis. I have also been taking MB12 sublingually with b12 oil. I was taking about 6grams sublingually and adenosylB12 (1/4 of 10gram tab) before switching to the b12 oil a couple of weeks ago 1 to 2 times per day. (Thinking that wasn't nearly enough.) 2 weeks ago I tried to drop down on folate, but started having mild sore throat, burning in chest, anxiety and reflux (I think) the same day I reduced. This was three days after I started the b12 oil. I went back to the 9.6gram dose and GI symptoms seemed to resolve temporarily, but anxiety and sleep issues continued. In a few days the burning in my stomach was back and more intense. The next day it moved into my arms with severe burning skin and slight numbness in palms. I saw my chiropractor who said it was a systemic reaction of some type. The burning then began moving around to other areas of my body and I realized it was neurological and is the symptom of b12 deficiency. I started taking b12 lozenges all day long and using the b12 oil 3 times per day, but the burning has continued like a bad sunburn moving from one area to another. I have never had these symptoms before. My nurse practitioner has done some blood work, some of which has come back and some we are waiting on. In the meantime, she has prescribed shots 6mg 2x/wk red blood cell folate 786 ng/ml.. b12 greater than 2000 (can't find my b12 test before starting methylation protocol. It wasn't this high but it was out of range and a Dr. told me she thought I wasn't using it.) potassium 4.1 calcium 9.8 magnesium 2.2 ferritin 23 There are other tests, but not sure what all is relevant. We are waiting on b1,2,3,6, vit. c and urine heavy metal panel. My fear is that I have functional b12 deficiency and the folate is causing neurological damage. My anxiety is extremely high. I would so appreciate help. Feel like I'm falling apart again.