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Frankenstein mice provides insights into the immunology of EBV infection

Discussion in 'Other Health News and Research' started by Ecoclimber, Sep 25, 2014.

  1. Ecoclimber

    Ecoclimber Senior Member

    Permission to repost from Prof. G

    Charcot Project: EBV in mIce

    Frankenstein mice provides insights into the immunology of EBV infection
    . #MSBlog #MSResearch

    "This study using a tansgenic mice, or Frankenstein mice, may of interest to those of you following the evolving story of EBV in MS. EBV does not have a non-human host; it is a virus that is human specific. Therefore to create an animal model you have to make the animal humanoid.

    In this case a mouse was created in the lab to have a human-like immune system that allows it be infected with EBV. The investigators then looked at the cellular immune responses to EBV; the so called CD8+ T cell responses.

    You may recall that Professor Pender has data suggesting MSers have a deficient CD8+ cytotoxic CD8+ T cell response to EBV. In this study they show that CD8+ are responsible for controlling the EBV virus viraemia in this animal model. Whether or not this is relevant to MS is a moot point, but does provide a model system for testing vaccines. The latter is clearly what we need to do the ultimate experiment; to whether or not EBV causes MS. If vaccinating high-risk people against EBV prevents them from developing MS then we will have proved that EBV is the cause of MS.

    This is similar to HPV and cervical cancer; vaccinating girls against this virus has resulted in a fall in incidence of cervical cancer, thus proving that HPV is a cause of cervical cancer."

    "The following is a link to Professor Pender's post; it is one of the most popular all-time posts on this blog."
    Guest Post: Professor Michael Pender - Multiple Sclerosis ..., 11 Feb 2014
    Professor Michael Pender graduated from The University of Queensland in 1974 with First Class Honours in Medicine and a University Medal. Over the next six years he trained as a physician and neurologist at the Royal ...

    Wesnes et al. Adoptive Transfer of EBV Specific CD8+ T Cell Clones Can Transiently Control EBV Infection in Humanized Mice. PLoS Pathog. 2014;10(8):e1004333. doi: 10.1371/journal.ppat.1004333

    Epstein Barr virus (EBV) infection expands CD8+ T cells specific for lytic antigens to high frequencies during symptomatic primary infection, and maintains these at significant numbers during persistence. Despite this, the protective function of these lytic EBV antigen-specific cytotoxic CD8+ T cells remains unclear.

    Methods & Results:
    Here we demonstrate that lytic EBV replication does not significantly contribute to virus-induced B cell proliferation in vitro and in vivo in a mouse model with reconstituted human immune system components (huNSG mice). However, we report a trend to reduction of EBV-induced lymphoproliferation outside of lymphoid organs upon diminished lytic replication. Moreover, we could demonstrate that CD8+ T cells against the lytic EBV antigen BMLF1 can eliminate lytically replicating EBV-transformed B cells from lymphoblastoid cell lines (LCLs) and in vivo, thereby transiently controlling high viremia after adoptive transfer into EBV infected huNSG mice.
    These findings suggest a protective function for lytic EBV antigen-specific CD8+ T cells against EBV infection and against virus-associated tumors in extra-lymphoid organs. These specificities should be explored for EBV-specific vaccine development.
    Last edited: Sep 25, 2014
    NK17, ukxmrv, shannah and 1 other person like this.
  2. heapsreal

    heapsreal iherb 10% discount code OPA989,

    australia (brisbane)
    good find. I think the researchers have treated a small number of MS patients with good results. We just need to get them to do this to cmv and hhv6??
    NK17 likes this.
  3. ukxmrv

    ukxmrv Senior Member

    Thanks for this. It's always interesting to see what Professor Pender is up to.
    NK17 likes this.
  4. NK17

    NK17 Senior Member

    The deadly triad: EBV - CMV - HHV6 A/B.
    heapsreal likes this.

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