Over the last 5 years or so I've been losing weight, feeling malnourished and sick and run down with no changes in diet or environment. Among other supplements, I started taking a B100 complex pill in September, and within a week I began having a terrible reaction. Now I know it was an overdose of at least folic acid, as well as the methylation cycle being clogged up and not working properly, causing further anxiety and general insanity. I was only on the B100 supplement for about 3 weeks before putting two and two together, and immediately stopped. That was over two months ago, and I'm recovering, but still feeling totally beat up and weak. The anxiety is almost unbearable, but I'm going through it. I got my results from the 23andme test, and found out I am homozygous for the following: SLC19a1 G80A MTRR A66G I'm still learning what all of this means, but I know for sure that my system got flooded with a form of folate that I couldn't process properly. I'm getting my level rechecked over the next few weeks, it takes time to get the results back. Originally my B6 levels were through the roof, but are back to normal again. B12 levels were always okay throughout this. I'm hetrozygous for the following: COMT V158M COMT H62H as well as MTHFR C677T and CBS C19150T CBS C699T and NOS3/eNOS A(-922)G This is sort of an overview of where I'm at. I've been taking small amounts of zinc, molybdenum, and magnesium bisglycinate, and also probiotics. My system reacts strongly to the omega 3 fish oil, I can't take it. I've been reading through this forum and others. If anyone has any ideas about how I can feel better, please respond. Thank you so much.