adreno
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http://www.dosfolat.de/literature/DOSFOLAT_Mohr_e.pdf
I guess the same would be the case for methylfolate?
I guess the same would be the case for methylfolate?
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Thanks, dbkita. I didn't know this about niacinamide, that's very interesting. Another good reason to take more.
I'm wondering whether the fact that folate can feed gut pathogens is part of the reason why so many here seem to have difficulty tolerating it? I have noticed lately that my yeast overgrowth seems to get worse when I up my folate dose. I get acne, and dry, scaly skin and itchy scalp.
Do you assess your yeast overgrowth with the acne, dry skin, and itchy scalp? Or are there other symptoms you notice? It definitely seems plausible, but then again, I would think that folate taken on an empty stomach would be absorbed fairly quickly in the upper intestines before the bugs get a chance to munch on it.
I have a stool test that shows fungal overgrowth (unknown taxonomy). I also suffer from frequent sinusitis, that I believe is of fungal origin. Some bloating and diarrhea. And or course the usual, fatigue, malaise, brain fog, OI, allergies, aso.Do you assess your yeast overgrowth with the acne, dry skin, and itchy scalp? Or are there other symptoms you notice? It definitely seems plausible, but then again, I would think that folate taken on an empty stomach would be absorbed fairly quickly in the upper intestines before the bugs get a chance to munch on it.
Hi dbitka, First I would like to Thank You for all that you share on these forums. Much of it is over my head but on good days, I am learning. I too have candida (I hate my toe fungus), I also have have high titters of hhv-6. I am currently taking acyclovir for the later. I am also doing SMP with metafolin. I have reduced to 1200mcg of metfolin trying to address my HORRID gas issues along with a tiny amount of acne confined to below each eye. Have you found that niacinamide reduces candida burden? Does niacinamide adversely affect methylation? Can you share what have you done for Candida other than the norm? I've also read that 10,000 mcg of biotin helps with candida???? Thanks in advance for any light you or anyone can shed.You are right in that it depends on which bugs and where they are located. Candida is not confined to the lower intestines. I learned that one the hard way.
My main strike weapons against Candida are diflucan and Nystatin. Maintenance is diet control, niaciamide and molybdenum. Niacinamide is also extremely useful to kill resistance to diflucan. Nystatin is not gut permeable and cleans the pipes. I take that may be 1-2 times a year for six weeks. Good probiotics are a must imo as well. I have to be eternally vigilant given my high glucocorticoid levels.Hi dbitka, First I would like to Thank You for all that you share on these forums. Much of it is over my head but on good days, I am learning. I too have candida (I hate my toe fungus), I also have have high titters of hhv-6. I am currently taking acyclovir for the later. I am also doing SMP with metafolin. I have reduced to 1200mcg of metfolin trying to address my HORRID gas issues along with a tiny amount of acne confined to below each eye. Have you found that niacinamide reduces candida burden? Does niacinamide adversely affect methylation? Can you share what have you done for Candida other than the norm? I've also read that 10,000 mcg of biotin helps with candida???? Thanks in advance for any light you or anyone can shed.
adreno I'm not sure of anything anymore either. Adding another item to the mix is daunting. I'm still trying to up intake of mb-12 to get back to where I was before I ran out of the enzymatic. The life extension mb12 messed with the mood, energy, bowel and sleep. I will NEVER run out of enzymatic again. Hugs to all
U can disregard most of this. I found your list of supps. on another post. Sorry for the duplication. Just lmk if you will the probiotic U R comfortable withThanks much for the post. I've done difulcan and nystatin in Jan. and Feb. My PCP is nervous-nelly with dif. and nys. I will put this out to my infectious disease dr who is handling the EBV situation. Looks like the missing links maybe Niacinamide ( won't interefere with methylation right) and molybdenum. What dosage of these should I consider? I take a mild probiotic. I've read some scary stuff about different strains. What probiotic are U comfortable with? Your suggestions are greatly appreciated dbkita.
That's what I'd always heard, yet my experience trumps that and it was an unexpected discovery to me.To my knowledge, fungi prefer an alkaline environment over acidic.
Clarifying: lots of sugar for three day in a row? The itchy scalp time for me. But I never get laid out like before, not even close. I still take biotin, for additional reasonsThat's what I'd always heard, yet my experience trumps that and it was an unexpected discovery to me.
I once tested it by having a quart of ice cream at a sitting. No problem. YMMV.
I'd discussed with somebody IRL last summer that it might even be creating supercharged bacteria. Even if somebody went to a doc with a stubborn infection and filled out their list of supplements, the doc might not suspect anything.http://www.dosfolat.de/literature/DOSFOLAT_Mohr_e.pdf
I guess the same would be the case for methylfolate?
Ergosterol is present in fungal cell membranes yet absent in animal cell membranes, and is a common target for antifungal drugs. Polyenes drugs such as nystatin and amphotericin B attack ergosterol in the cell walls of Candida, poking holes in the walls, leading to destruction of the yeast cell. Azoles such as fluconazole (Diflucan) and itraconazole (Sporanox) inhibit ergosterol production, as does terbinafine (Lamisil), and this inhibits Candida growth.
It has been shown in laboratory experiments that folic acid (folate) is required by Candida to create ergosterol. By disturbing folate metabolism with the antifolate drug pyrimethamine, scientists were able to increase the effectiveness of ergosterol inhibiting antifungals.
http://www.ncbi.nlm.nih.gov/pubmed/17046206
If denying Candida folate at the cellular level is antifungal, does this mean supplementing folate stimulates Candida growth? Might taking folate supplements interfere with antifungals?
I could not find any scientific research into this so I decided to do a simple test myself. I half filled a couple of jars with water, then added sugar and baker's yeast. To one jar I added 2 tablets (1000mcg) of folate (crushed and mixed with water first). Over the next 24 hours both mixtures produced strong yeast growth evidenced by bubbling, scum/froth and a strong yeast smell. The folate mixture produced slightly more yeast scum and bubbling.
After 24 hours I added a 250mg capsule of the antifungal amphotericin B to both samples, and also skimmed the yeast scum from the surface. 12 hours later and only the folate mixture was still bubbling. At a much reduced rate than before the AMB was added, but it was still fermenting, whereas the control mixture was not. The folate mixture also had slightly more yeast scum on top, but there was not a huge difference, so apparently the control mixture had continued to ferment for some time before the AMB fully inhibited yeast growth.
I did the exact same test with a capsule of B multivitamins, and the results were the same as the control (no bubbling, no more yeast scum).