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Folate Receptor Alpha Autoantibodies, ASD and Thyroid Function

Discussion in 'Other Health News and Research' started by Marco, Sep 29, 2014.

  1. Marco

    Marco Grrrrrrr!

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    This paper suggests that autoantibodies to the folate receptor alpha may interfere with thyroid function in some ASD patients :

    Folate Receptor Alpha Autoantibodies Modulate Thyroid Function in Autism Spectrum Disorder

    http://najms.net/wp-content/uploads/v07i02p053.pdf

    Interesting in the context that numerous recent papers have suggested that ASD may involve defects in the mitochondrial respiratory chain in which folate plays a key role :

    Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285768/

    OK, it's the same authors but with over 150 citations they're either doing something right or something very wrong.

    Also, in one of the 'Dubbo' papers, those who developed 'chronic fatigue' following EBV infection had altered gene expression including the FOLR1 - folate receptor 1.


    Preliminary evidence of mitochondrial dysfunction associated with post-infective fatigue after acute infection with Epstein Barr Virus

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1373655/

    Just one of a number of genes differentially expressed and the authors do state the evidence is preliminary but an interesting pathway that may be susceptible to both viral and autoimmune attack.

    Probably very familiar territory for those following methylation protocols.
     
    ahmo, Sea, Valentijn and 1 other person like this.

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