To mention a thought which occurred to me after listening to Cheney's 2005 talk: he says that CFS problems arise from Diastolic Dysfunction (which itself arises from mito dysfunction). When heart muscle gets over-taxed, it releases BNP (called Brain Natriuretic Peptide, which was originally found in tiny amount in the brain, but is now well-known to be a marker for heart failure). BNP is a diuretic, so lessening of blood volume eases the workload of the heart (also causing polyuria). However, in some people, that results in Orthostatic Intolerance of various types. While Florinef can help with the OI, it unfortunately might also counteract the body's effort to try and protect the heart. I don't know if Cheney mentions that, or even if the concern is valid. It's just a thought.