Hello friends, It has been a while. If you guys are not familiar with my work, I created this thread... Fixing Leaky Gut = One Possible ME/CFS Cure ( http://forums.phoenixrising.me/index.php?threads/fixing-leaky-gut-one-possible-me-cfs-cure.39712/ ) Sorry that I haven't kept you guys up-to-date, but I haven't been feeling well. I have made some progress that I would like to share with you guy. I think to fully recover from Leaky Gut you need to have the following items in place and why... 1. Fully-functional methylation cycle - Follow the different methylation protocols on this forum. They work. I think having a fully-functional cycle allows your body to create its own intestinal coating through fructose-6-phosphate ( http://oregonstate.edu/dept/biochem/hhmi/hhmiclasses/bb450/winter2002/ch16/c16bas.htm ). 2. Great pH balance - Having great pH balance allows your body to create adequate stomach acid for nutrient absorption and have the resiliency to handle organic acids produced in your gut. To get my pH back into balance, I took calcium hydroxyapatite / magnesium glycinate. It appeared my body could not handle calcium bonded with organic acids such as citric and malic acids. I think taking formulas like Acid-A-Cal ( http://www.enzymatictherapy.com/Products/Bone-and-Joint/Joint/01151-Acid-A-Cal.aspx ) and Acid-A-Med ( http://www.europharmausa.com/products/acid-a-med/ ) would also be beneficial to help in calcium metabolism. Oh yeah, don't forget the typical calcium co-factors such as Vitamin C, Zinc, Copper, Vitamin D, Vitamin K, and Boron. Now with the aforementioned items in place, I notice when I take 1000 mg - 2000 mg of Glutamine that my intestines is now coated. However, depending on the state of your body, coated-intestines block nutrient absorption at least in my case. To get over this blockage in nutrient absorption, I would take InterFase ( https://www.protherainc.com/prod/proddetail.asp?ID=K-INT-12 ) to eat the coating off my intestine walls, eat good food to get my body back in order, and then try a new experiment. When my intestines were coated during this round of experimentation and the past, I noticed the first thing that starts failing is my adrenals. In the past, one thing that would perk up my adrenals is butyric acid, one of the organic acids that our gut bacteria are supposed to produce. So, I took some butyric acid and my adrenals felt somewhat nourished. Like I stated earlier, when my intestines are coated, I felt that my body was not absorbing my food properly. My gut was able to withstand the acidity of the butyric acid, but it was not absorbing my food properly. I think in a fully healthy body most of the food absorption should take place in the small intestines, while the large intestines is suppose to absorb water and electrolytes; provide some nutrient absorption; ferment fiber to produce organic acids; produce additional vitamins; and store fecal matter. On the other hand, the large intestines of a person with leaky gut is huge requirement for additional nutrient absorption. I hoped by adding probiotics would facilitate additional nutrient absorption in the large intestines, but it did not. Perhaps, the probiotics I took was not strong enough to do so. For my next experiment, I may try to take Molkosan ( http://www.avogel.co.uk/food/molkosan-digestion/ ) with or without coated-intestines. I have not decided. I think Molkosan would encourage the correct pH in the colon. I feel weak and tired. I have been battled health issues non-stop since 2009. I am tired. I need your help guys to pick up where I left off. It will not be another two weeks to a month until I get the urge to experiment again.