I don't know if I have picked the right forum for this question, but since this question is about a supplement for pyroluria I chose this one. I was diagnosed as having pyroluria disorder. When I read more about it, I was elated as it I explained numerous symptoms I have had for years and I read stories of others that said how the simple diagnosis had been a major piece of the puzzle in their CFS condition and it helped them become close to normal again. Unfortunately it did not work out that way for me. I actually felt worse. I kept on with the protocol since I had positive blood test for it and was classic symptom sufferer and read where some others feel worse before feeling better. On the treatment I felt a LOT more lethargic, greater difficulty concentrating and sticking to tasks, a lot more headaches, more apathetic. Recently I had been feeling quite unwell so backed off on all my supplements. As I improved I started to add a few back in haphazard manner, it was then that I able to isolate the P5P as making me feel so crappy (headaches + sleepiness + brain fog + feeling of numbness in the prefrontal cortex region very soon after taking just that). For the past 2 years I have generally taken all my supps at the same time (start of the day + end of the day). Like many here I am on swag of different things, and feeling worse after starting on the pyroluria protocol, just made me end up taking more to help find the missing piece to my health puzzle. After all that....can anyone here relate to this or know of others who had bad reaction to P5P? I did a bit of a google search and not much came up. Pretty much all the articles raved about it being so good for you and better than B6. My doctor knows I have complained about the pyroluria treatment not working but I am going to email him about the P5P, but I suspect he might not have any answer on it.