I have been doing the Methylation Protocol off and on since November, and I have seen some very random results with it. I take sublingual Methyl B12 at least every other day, and Adeno b12 two to three times a week. I take Metafolin, Acetyl-L-carnitine, and potassium, plus Vit C and multi-vitamin. I do notice a seeming increase in ability to exert myself with the Adeno b12, but aside from some increased energy, the Methyl-b12 does not seem to be doing much. In fact, when I do take it, it makes me really cold, and it not a pleasant side effect. What could be causing the cold issues? This only happens with Methyl b12 or caffeine, nothing else. On the other hand, the benefits are enough that I do want to keep taking it. Any ideas? Also, the B12 seems to be ramping up immune response, in that a cold i have had for almost three weeks now has not resolved itself. Nasal/sinus congestion has lingered rather uncomfortably for some time, and I would like to diminish that.